Threatened abortion: A risk factor for poor pregnancy outcome, a population-based screening study

Joshua L. Weiss, Fergal D. Malone, John Vidaver, Robert H. Ball, David A. Nyberg, Christine H. Comstock, Gary Hankins, Richard L. Berkowitz, Susan J. Gross, Lorraine Dugoff, Ilan E. Timor-Tritsch, Mary E. D'Alton

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Objective: The purpose of this study was to determine whether patients with first-trimester threatened abortion are at increased risk for poor pregnancy outcome. Study design: A large prospective multicenter database was studied. Subjects were divided into three groups: (1) no bleeding, (2) light bleeding, and (3) heavy bleeding. Univariate and multivariable logistic regression analyses were used. Results: The study comprised 16,506 patients: 14,160 patients without bleeding, 2094 patients with light bleeding, and 252 patients with heavy bleeding. Patients with vaginal bleeding, light or heavy, were more likely to experience a spontaneous loss before 24 weeks of gestation (odds ratio, 2.5 and 4.2, respectively) and cesarean delivery (odds ratio, 1.1 and 1.4, respectively). Light bleeding subjects were more likely to have preeclampsia (odds ratio, 1.5), preterm delivery (odds ratio, 1.3), and placental abruption (odds ratio, 1.6). Heavy vaginal bleeding subjects were more likely to have intrauterine growth restriction (odds ratio, 2.6), preterm delivery (odds ratio, 3.0), preterm premature rupture of membranes (odds ratio, 3.2), and placental abruption (odds ratio, 3.6). Conclusion: First-trimester vaginal bleeding is an independent risk factor for adverse obstetric outcome that is directly proportional to the amount of bleeding.

Original languageEnglish (US)
Pages (from-to)745-750
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume190
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Threatened Abortion
Pregnancy Outcome
Odds Ratio
Hemorrhage
Population
Uterine Hemorrhage
Abruptio Placentae
First Pregnancy Trimester
Pre-Eclampsia
Obstetrics
Logistic Models
Regression Analysis
Databases

Keywords

  • Placental abruption
  • Preterm delivery
  • Preterm premature rupture of membranes
  • Spontaneous pregnancy loss
  • Threatened abortion

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Weiss, J. L., Malone, F. D., Vidaver, J., Ball, R. H., Nyberg, D. A., Comstock, C. H., ... D'Alton, M. E. (2004). Threatened abortion: A risk factor for poor pregnancy outcome, a population-based screening study. American Journal of Obstetrics and Gynecology, 190(3), 745-750. https://doi.org/10.1016/j.ajog.2003.09.023

Threatened abortion : A risk factor for poor pregnancy outcome, a population-based screening study. / Weiss, Joshua L.; Malone, Fergal D.; Vidaver, John; Ball, Robert H.; Nyberg, David A.; Comstock, Christine H.; Hankins, Gary; Berkowitz, Richard L.; Gross, Susan J.; Dugoff, Lorraine; Timor-Tritsch, Ilan E.; D'Alton, Mary E.

In: American Journal of Obstetrics and Gynecology, Vol. 190, No. 3, 03.2004, p. 745-750.

Research output: Contribution to journalArticle

Weiss, JL, Malone, FD, Vidaver, J, Ball, RH, Nyberg, DA, Comstock, CH, Hankins, G, Berkowitz, RL, Gross, SJ, Dugoff, L, Timor-Tritsch, IE & D'Alton, ME 2004, 'Threatened abortion: A risk factor for poor pregnancy outcome, a population-based screening study', American Journal of Obstetrics and Gynecology, vol. 190, no. 3, pp. 745-750. https://doi.org/10.1016/j.ajog.2003.09.023
Weiss, Joshua L. ; Malone, Fergal D. ; Vidaver, John ; Ball, Robert H. ; Nyberg, David A. ; Comstock, Christine H. ; Hankins, Gary ; Berkowitz, Richard L. ; Gross, Susan J. ; Dugoff, Lorraine ; Timor-Tritsch, Ilan E. ; D'Alton, Mary E. / Threatened abortion : A risk factor for poor pregnancy outcome, a population-based screening study. In: American Journal of Obstetrics and Gynecology. 2004 ; Vol. 190, No. 3. pp. 745-750.
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abstract = "Objective: The purpose of this study was to determine whether patients with first-trimester threatened abortion are at increased risk for poor pregnancy outcome. Study design: A large prospective multicenter database was studied. Subjects were divided into three groups: (1) no bleeding, (2) light bleeding, and (3) heavy bleeding. Univariate and multivariable logistic regression analyses were used. Results: The study comprised 16,506 patients: 14,160 patients without bleeding, 2094 patients with light bleeding, and 252 patients with heavy bleeding. Patients with vaginal bleeding, light or heavy, were more likely to experience a spontaneous loss before 24 weeks of gestation (odds ratio, 2.5 and 4.2, respectively) and cesarean delivery (odds ratio, 1.1 and 1.4, respectively). Light bleeding subjects were more likely to have preeclampsia (odds ratio, 1.5), preterm delivery (odds ratio, 1.3), and placental abruption (odds ratio, 1.6). Heavy vaginal bleeding subjects were more likely to have intrauterine growth restriction (odds ratio, 2.6), preterm delivery (odds ratio, 3.0), preterm premature rupture of membranes (odds ratio, 3.2), and placental abruption (odds ratio, 3.6). Conclusion: First-trimester vaginal bleeding is an independent risk factor for adverse obstetric outcome that is directly proportional to the amount of bleeding.",
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AU - Hankins, Gary

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