Abstract
It was recently suggested that the periodic and fractal precipitation of calcium salts and proteins in cholesterol gallstonesis closely related to the process of stone formation. The present study is to mimic the process of gallstone growth in vitro. We demonstrate for the first time that a three-dimensional structure of periodic rings (Liesegang ring) and/or fractal patterns can be produced by metal ion and deoxycholate precipitation, which are similar to gallstones. Precipitation in a periodic pattern occurs more often than in a fractal structure. Using X-ray diffraction, polarized light microscope, Fourier transform-infrared (FT-IR), and extended X-ray absorption fine structure (EXAFS), we studied the pattern formation mechanisms of both types of structures. The results indicate that the rate of nucleation in the crystal growth is a crucial element to affect the pattern formation. The pattern selection between periodic and fractal type depends on the crystal growth speed and the rate of nucleation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8602-8605 |
| Number of pages | 4 |
| Journal | Journal of Physical Chemistry B |
| Volume | 103 |
| Issue number | 40 |
| State | Published - Oct 7 1999 |
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ASJC Scopus subject areas
- Physical and Theoretical Chemistry
Cite this
Three-dimensional Periodic and Fractal Precipitation in Metal Ion-Deoxycholate System : A Model for Gallstone Formation. / Xie, Datao; Wu, Jinguang; Xu, Guangxian; Ouyang, Qi; Soloway, R. D.; Hu, Tiandou.
In: Journal of Physical Chemistry B, Vol. 103, No. 40, 07.10.1999, p. 8602-8605.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Three-dimensional Periodic and Fractal Precipitation in Metal Ion-Deoxycholate System
T2 - A Model for Gallstone Formation
AU - Xie, Datao
AU - Wu, Jinguang
AU - Xu, Guangxian
AU - Ouyang, Qi
AU - Soloway, R. D.
AU - Hu, Tiandou
PY - 1999/10/7
Y1 - 1999/10/7
N2 - It was recently suggested that the periodic and fractal precipitation of calcium salts and proteins in cholesterol gallstonesis closely related to the process of stone formation. The present study is to mimic the process of gallstone growth in vitro. We demonstrate for the first time that a three-dimensional structure of periodic rings (Liesegang ring) and/or fractal patterns can be produced by metal ion and deoxycholate precipitation, which are similar to gallstones. Precipitation in a periodic pattern occurs more often than in a fractal structure. Using X-ray diffraction, polarized light microscope, Fourier transform-infrared (FT-IR), and extended X-ray absorption fine structure (EXAFS), we studied the pattern formation mechanisms of both types of structures. The results indicate that the rate of nucleation in the crystal growth is a crucial element to affect the pattern formation. The pattern selection between periodic and fractal type depends on the crystal growth speed and the rate of nucleation.
AB - It was recently suggested that the periodic and fractal precipitation of calcium salts and proteins in cholesterol gallstonesis closely related to the process of stone formation. The present study is to mimic the process of gallstone growth in vitro. We demonstrate for the first time that a three-dimensional structure of periodic rings (Liesegang ring) and/or fractal patterns can be produced by metal ion and deoxycholate precipitation, which are similar to gallstones. Precipitation in a periodic pattern occurs more often than in a fractal structure. Using X-ray diffraction, polarized light microscope, Fourier transform-infrared (FT-IR), and extended X-ray absorption fine structure (EXAFS), we studied the pattern formation mechanisms of both types of structures. The results indicate that the rate of nucleation in the crystal growth is a crucial element to affect the pattern formation. The pattern selection between periodic and fractal type depends on the crystal growth speed and the rate of nucleation.
UR - http://www.scopus.com/inward/record.url?scp=0000962261&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0000962261&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0000962261
VL - 103
SP - 8602
EP - 8605
JO - Journal of Physical Chemistry B Materials
JF - Journal of Physical Chemistry B Materials
SN - 1520-6106
IS - 40
ER -