Three-dimensional Periodic and Fractal Precipitation in Metal Ion-Deoxycholate System: A Model for Gallstone Formation

Datao Xie, Jinguang Wu, Guangxian Xu, Qi Ouyang, R. D. Soloway, Tiandou Hu

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

It was recently suggested that the periodic and fractal precipitation of calcium salts and proteins in cholesterol gallstonesis closely related to the process of stone formation. The present study is to mimic the process of gallstone growth in vitro. We demonstrate for the first time that a three-dimensional structure of periodic rings (Liesegang ring) and/or fractal patterns can be produced by metal ion and deoxycholate precipitation, which are similar to gallstones. Precipitation in a periodic pattern occurs more often than in a fractal structure. Using X-ray diffraction, polarized light microscope, Fourier transform-infrared (FT-IR), and extended X-ray absorption fine structure (EXAFS), we studied the pattern formation mechanisms of both types of structures. The results indicate that the rate of nucleation in the crystal growth is a crucial element to affect the pattern formation. The pattern selection between periodic and fractal type depends on the crystal growth speed and the rate of nucleation.

Original languageEnglish (US)
Pages (from-to)8602-8605
Number of pages4
JournalJournal of Physical Chemistry B
Volume103
Issue number40
StatePublished - Oct 7 1999

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Deoxycholic Acid
Fractals
Metal ions
fractals
metal ions
Crystallization
Crystal growth
Nucleation
crystal growth
nucleation
Cholesterol
X ray absorption
Light polarization
rings
cholesterol
Calcium
Fourier transforms
Microscopes
Salts
polarized light

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Three-dimensional Periodic and Fractal Precipitation in Metal Ion-Deoxycholate System : A Model for Gallstone Formation. / Xie, Datao; Wu, Jinguang; Xu, Guangxian; Ouyang, Qi; Soloway, R. D.; Hu, Tiandou.

In: Journal of Physical Chemistry B, Vol. 103, No. 40, 07.10.1999, p. 8602-8605.

Research output: Contribution to journalArticle

Xie, Datao ; Wu, Jinguang ; Xu, Guangxian ; Ouyang, Qi ; Soloway, R. D. ; Hu, Tiandou. / Three-dimensional Periodic and Fractal Precipitation in Metal Ion-Deoxycholate System : A Model for Gallstone Formation. In: Journal of Physical Chemistry B. 1999 ; Vol. 103, No. 40. pp. 8602-8605.
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