Thromboxane synthase inhibition and cardiopulmonary function during endotoxemia in sheep

K. Fujioka, K. Sugi, T. Isago, J. T. Flynn, L. D. Traber, David Herndon, D. L. Traber

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We studied the cardiopulmonary response to endotoxin (lipopolysaccharide, LPS) in sheep with and without the administration of a thromboxane synthase inhibitor, OKY-046. The animals were instrumented for crystalographic dimension analysis of the left ventricle (LV) and for measurement of LV, aortic, left atrial, and pulmonary arterial pressures and cardiac index, as well as lung lymph flow. They received 1.0 μg/kg of Escherichia coli LPS with (n = 8) and without (n = 8) OKY-046 (10 mg/kg bolus, then 10 μg · kg-1 · min-1). OKY-046 prevented the increase of pulmonary arterial pressure and the decrease of cardiac index that occurred during the early phase of endotoxemia. Between 8 and 12 h after LPS, cardiac index increased from 6.8 ± 0.7 to 8.9 ± 0.5 l · min-1 · m-2. Concomitantly, the end-systolic pressure-diameter relationship (ESPDR, sensitive myocardial contractility index) significantly decreased from 14.7 ± 0.6 to 7.7 ± 0.7. Other indexes of the LV contractility (+dP/dt(max)) were also reduced. OKY-046 prevented the decreases of ESPDR and +dP/dt(max). OKY-046 also attenuated the increased lung lymph flow changes seen with LPS.

Original languageEnglish (US)
Pages (from-to)1376-1381
Number of pages6
JournalJournal of Applied Physiology
Volume71
Issue number4
StatePublished - 1991

Fingerprint

Endotoxemia
Thromboxanes
Sheep
Lipopolysaccharides
Heart Ventricles
Lung
Lymph
Arterial Pressure
Endotoxins
ozagrel
Escherichia coli
Blood Pressure

Keywords

  • cardiac dysfunction
  • end-systolic pressure-diameter relationship
  • endotoxin
  • lung microvascular permeability
  • lung-lymph fistula
  • myocardial performance
  • sepsis
  • sonomicrometer

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Fujioka, K., Sugi, K., Isago, T., Flynn, J. T., Traber, L. D., Herndon, D., & Traber, D. L. (1991). Thromboxane synthase inhibition and cardiopulmonary function during endotoxemia in sheep. Journal of Applied Physiology, 71(4), 1376-1381.

Thromboxane synthase inhibition and cardiopulmonary function during endotoxemia in sheep. / Fujioka, K.; Sugi, K.; Isago, T.; Flynn, J. T.; Traber, L. D.; Herndon, David; Traber, D. L.

In: Journal of Applied Physiology, Vol. 71, No. 4, 1991, p. 1376-1381.

Research output: Contribution to journalArticle

Fujioka, K, Sugi, K, Isago, T, Flynn, JT, Traber, LD, Herndon, D & Traber, DL 1991, 'Thromboxane synthase inhibition and cardiopulmonary function during endotoxemia in sheep', Journal of Applied Physiology, vol. 71, no. 4, pp. 1376-1381.
Fujioka K, Sugi K, Isago T, Flynn JT, Traber LD, Herndon D et al. Thromboxane synthase inhibition and cardiopulmonary function during endotoxemia in sheep. Journal of Applied Physiology. 1991;71(4):1376-1381.
Fujioka, K. ; Sugi, K. ; Isago, T. ; Flynn, J. T. ; Traber, L. D. ; Herndon, David ; Traber, D. L. / Thromboxane synthase inhibition and cardiopulmonary function during endotoxemia in sheep. In: Journal of Applied Physiology. 1991 ; Vol. 71, No. 4. pp. 1376-1381.
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