Thymoquinone blocks pSer/pThr recognition by plk1 polo-box domain as a phosohate mimic

Keyphrases

• Thymoquinone 100%
• Polo-like Kinase 1 (PLK1) 100%
• Polo-box Domain 100%
• Small Molecules 40%
• Protein-protein Interaction 20%
• Medicinal Chemistry 20%
• Binding Protein 20%
• Phosphorylation 20%
• Oncogenesis 20%
• Antitumor Agents 20%
• Substrate Recognition 20%
• Binding Mode 20%
• Binding Pocket 20%
• Phosphopeptides 20%
• Recognition Site 20%
• Crystallographic Study 20%
• Phosphoserine 20%
• Phosphate Group 20%
• Cation-anion Interaction 20%
• Water Bridge 20%
• Non-covalent Binding 20%
• Conserved Water 20%
• Mitotic Regulator 20%
• Phosphothreonine 20%
• Competition Strategy 20%

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• Polo-Like Kinase 1 100%
• Binding Protein 50%
• Protein-Protein Interaction 50%
• Carcinogenesis 50%
• Phosphoserine 50%
• Phosphopeptide 50%