Thyroid cancer occurring as a late consequence of head and neck irradiation. Evaluation of 1056 patients

M. J. Favus, A. B. Schneider, M. E. Stachura, J. E. Arnold, U. Y. Ryo, S. M. Pinsky, M. Colman, M. J. Arnold, L. A. Frohman

Research output: Contribution to journalArticle

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Abstract

From January 1 to September 30, 1974, examination was made of 1056 of 5266 subjects (20.1%) who had received therapeutic irradiation primarily for infections and inflammatory disease of the upper respiratory tract at an institution during the 1940's and 1950's. The tonsillar and nasopharyngeal region was the treatment site in 85% of those examined. Palpable nodular thyroid disease was found in 16.5%, and nonpalpable lesions were detected by 99mTc pertechnetate thyroid imaging in an additional 10.7%, for a prevalence of nodular disease of 27.2%. Operation on 71% with nodular disease revealed thyroid cancer in 33% (60 of 182). Preliminary analysis for potential risk factors suggests a correlation between radiation exposure and the presence of thyroid benign (P<0.001). These findings indicate that nodular thyroid disease, both benigb and malignant, continues as a major health problem for at least 35 yr in exposed subjects.

Original languageEnglish (US)
Pages (from-to)1019-1025
Number of pages7
JournalNew England Journal of Medicine
Volume294
Issue number19
StatePublished - 1976
Externally publishedYes

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Thyroid Diseases
Thyroid Neoplasms
Thyroid Gland
Neck
Head
Respiratory Tract Diseases
Sodium Pertechnetate Tc 99m
Health
Therapeutics
Infection
Radiation Exposure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Favus, M. J., Schneider, A. B., Stachura, M. E., Arnold, J. E., Ryo, U. Y., Pinsky, S. M., ... Frohman, L. A. (1976). Thyroid cancer occurring as a late consequence of head and neck irradiation. Evaluation of 1056 patients. New England Journal of Medicine, 294(19), 1019-1025.

Thyroid cancer occurring as a late consequence of head and neck irradiation. Evaluation of 1056 patients. / Favus, M. J.; Schneider, A. B.; Stachura, M. E.; Arnold, J. E.; Ryo, U. Y.; Pinsky, S. M.; Colman, M.; Arnold, M. J.; Frohman, L. A.

In: New England Journal of Medicine, Vol. 294, No. 19, 1976, p. 1019-1025.

Research output: Contribution to journalArticle

Favus, MJ, Schneider, AB, Stachura, ME, Arnold, JE, Ryo, UY, Pinsky, SM, Colman, M, Arnold, MJ & Frohman, LA 1976, 'Thyroid cancer occurring as a late consequence of head and neck irradiation. Evaluation of 1056 patients', New England Journal of Medicine, vol. 294, no. 19, pp. 1019-1025.
Favus MJ, Schneider AB, Stachura ME, Arnold JE, Ryo UY, Pinsky SM et al. Thyroid cancer occurring as a late consequence of head and neck irradiation. Evaluation of 1056 patients. New England Journal of Medicine. 1976;294(19):1019-1025.
Favus, M. J. ; Schneider, A. B. ; Stachura, M. E. ; Arnold, J. E. ; Ryo, U. Y. ; Pinsky, S. M. ; Colman, M. ; Arnold, M. J. ; Frohman, L. A. / Thyroid cancer occurring as a late consequence of head and neck irradiation. Evaluation of 1056 patients. In: New England Journal of Medicine. 1976 ; Vol. 294, No. 19. pp. 1019-1025.
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AU - Schneider, A. B.

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AU - Arnold, J. E.

AU - Ryo, U. Y.

AU - Pinsky, S. M.

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AU - Arnold, M. J.

AU - Frohman, L. A.

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