Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia

for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objective: To assess whether treatment of pregnant women with subclinical hypothyroidism or hypothyroxinemia alters neonatal TSH results. Study design: A planned secondary analysis of data from two multi-center randomized, double-masked, placebo-controlled thyroxine replacement trials in pregnant women with either subclinical hypothyroidism or hypothyroxinemia. Infant heel-stick specimens were obtained before discharge. We compared TSH levels between neonates born to mothers allocated to treatment or placebo within each trial and between neonates in the placebo groups. Multiples of means were generated for day-of-life-specific data. Results: Neonatal TSH values were available for 573/677 (84.6%) newborns from the subclinical hypothyroidism trial and 461/526 (87.6%) newborns from the hypothyroxinemia trial. Neonatal TSH values did not differ in either trial by treatment group or between placebo groups (P > 0.05 for all comparisons). Conclusions: Neonatal TSH values did not differ with thyroid hormone replacement in pregnancies diagnosed with subclinical hypothyroidism or hypothyroxinemia.

Original languageEnglish (US)
Pages (from-to)1490-1495
Number of pages6
JournalJournal of Perinatology
Volume38
Issue number11
DOIs
StatePublished - Nov 1 2018

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia'. Together they form a unique fingerprint.

  • Cite this

    for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (2018). Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia. Journal of Perinatology, 38(11), 1490-1495. https://doi.org/10.1038/s41372-018-0213-9