Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis

Nahed Ismail; Jere W. McBride

doi:10.1016/j.cll.2017.01.006

Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis

Nahed Ismail, Jere W. McBride

Pathology

Research output: Contribution to journal › Review article › peer-review

140 Scopus citations

Abstract

Human ehrlichiosis and anaplasmosis are acute febrile tick-borne infectious diseases caused by various members from the genera Ehrlichia and Anaplasma. Ehrlichia chaffeensis is the major etiologic agent of human monocytotropic ehrlichiosis (HME), while Anaplasma phagocytophilum is the major cause of human granulocytic anaplasmosis (HGA). The clinical manifestations of HME and HGA ranges from subclinical to potentially life-threatening diseases associated with multi-organ failure. Macrophages and neutrophils are the major target cells for Ehrlichia and Anaplasma, respectively. The threat to public health is increasing with newly emerging ehrlichial and anaplasma agents, yet vaccines for human ehrlichioses and anaplasmosis are not available, and therapeutic options are limited. This article reviews recent advances in the understanding of HME and HGA.

Original language	English (US)
Pages (from-to)	317-340
Number of pages	24
Journal	Clinics in Laboratory Medicine
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/j.cll.2017.01.006
State	Published - Jun 2017

Keywords

Anaplasmosis
Diagnosis
Ehrlichiosis
Immunity
Pathogenesis

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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10.1016/j.cll.2017.01.006

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title = "Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis",

abstract = "Human ehrlichiosis and anaplasmosis are acute febrile tick-borne infectious diseases caused by various members from the genera Ehrlichia and Anaplasma. Ehrlichia chaffeensis is the major etiologic agent of human monocytotropic ehrlichiosis (HME), while Anaplasma phagocytophilum is the major cause of human granulocytic anaplasmosis (HGA). The clinical manifestations of HME and HGA ranges from subclinical to potentially life-threatening diseases associated with multi-organ failure. Macrophages and neutrophils are the major target cells for Ehrlichia and Anaplasma, respectively. The threat to public health is increasing with newly emerging ehrlichial and anaplasma agents, yet vaccines for human ehrlichioses and anaplasmosis are not available, and therapeutic options are limited. This article reviews recent advances in the understanding of HME and HGA.",

keywords = "Anaplasmosis, Diagnosis, Ehrlichiosis, Immunity, Pathogenesis",

author = "Nahed Ismail and McBride, {Jere W.}",

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year = "2017",

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doi = "10.1016/j.cll.2017.01.006",

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TY - JOUR

T1 - Tick-Borne Emerging Infections

T2 - Ehrlichiosis and Anaplasmosis

AU - Ismail, Nahed

AU - McBride, Jere W.

PY - 2017/6

Y1 - 2017/6

N2 - Human ehrlichiosis and anaplasmosis are acute febrile tick-borne infectious diseases caused by various members from the genera Ehrlichia and Anaplasma. Ehrlichia chaffeensis is the major etiologic agent of human monocytotropic ehrlichiosis (HME), while Anaplasma phagocytophilum is the major cause of human granulocytic anaplasmosis (HGA). The clinical manifestations of HME and HGA ranges from subclinical to potentially life-threatening diseases associated with multi-organ failure. Macrophages and neutrophils are the major target cells for Ehrlichia and Anaplasma, respectively. The threat to public health is increasing with newly emerging ehrlichial and anaplasma agents, yet vaccines for human ehrlichioses and anaplasmosis are not available, and therapeutic options are limited. This article reviews recent advances in the understanding of HME and HGA.

AB - Human ehrlichiosis and anaplasmosis are acute febrile tick-borne infectious diseases caused by various members from the genera Ehrlichia and Anaplasma. Ehrlichia chaffeensis is the major etiologic agent of human monocytotropic ehrlichiosis (HME), while Anaplasma phagocytophilum is the major cause of human granulocytic anaplasmosis (HGA). The clinical manifestations of HME and HGA ranges from subclinical to potentially life-threatening diseases associated with multi-organ failure. Macrophages and neutrophils are the major target cells for Ehrlichia and Anaplasma, respectively. The threat to public health is increasing with newly emerging ehrlichial and anaplasma agents, yet vaccines for human ehrlichioses and anaplasmosis are not available, and therapeutic options are limited. This article reviews recent advances in the understanding of HME and HGA.

KW - Anaplasmosis

KW - Diagnosis

KW - Ehrlichiosis

KW - Immunity

KW - Pathogenesis

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M3 - Review article

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AN - SCOPUS:85016014815

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JO - Clinics in Laboratory Medicine

JF - Clinics in Laboratory Medicine

IS - 2

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Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis

Abstract

Keywords

ASJC Scopus subject areas

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