Tick–virus–host interactions at the cutaneous interface: The nidus of flavivirus transmission

Meghan E. Hermance, Saravanan Thangamani

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Tick-borne viral diseases continue to emerge in the United States, as clearly evident from the increase in Powassan encephalitis virus, Heartland virus, and Bourbon virus infections. Tick-borne flaviviruses (TBFVs) are transmitted to the mammalian host along with the infected tick saliva during blood-feeding. Successful tick feeding is facilitated by a complex repertoire of pharmacologically active salivary proteins/factors in tick saliva. These salivary factors create an immunologically privileged micro-environment in the host’s skin that influences virus transmission and pathogenesis. In this review, we will highlight tick determinants of TBFV transmission with a special emphasis on tick–virus–host interactions at the cutaneous interface.

Original languageEnglish (US)
Article number362
Issue number7
StatePublished - Jul 2018


  • Cutaneous
  • Feeding
  • Flavivirus
  • Interface
  • Saliva
  • Skin
  • Tick

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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