Tick–virus–host interactions at the cutaneous interface: The nidus of flavivirus transmission

Meghan Hermance, Saravanan Thangamani

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Tick-borne viral diseases continue to emerge in the United States, as clearly evident from the increase in Powassan encephalitis virus, Heartland virus, and Bourbon virus infections. Tick-borne flaviviruses (TBFVs) are transmitted to the mammalian host along with the infected tick saliva during blood-feeding. Successful tick feeding is facilitated by a complex repertoire of pharmacologically active salivary proteins/factors in tick saliva. These salivary factors create an immunologically privileged micro-environment in the host’s skin that influences virus transmission and pathogenesis. In this review, we will highlight tick determinants of TBFV transmission with a special emphasis on tick–virus–host interactions at the cutaneous interface.

Original languageEnglish (US)
Article number362
JournalViruses
Volume10
Issue number7
DOIs
StatePublished - Jul 1 2018

Fingerprint

Flavivirus
Ticks
Skin
Virus Diseases
Saliva
Encephalitis Viruses
Tick-Borne Diseases
Salivary Proteins and Peptides
Tick-Borne Encephalitis Viruses
Tick-Borne Encephalitis
Viruses

Keywords

  • Cutaneous
  • Feeding
  • Flavivirus
  • Interface
  • Saliva
  • Skin
  • Tick

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Tick–virus–host interactions at the cutaneous interface : The nidus of flavivirus transmission. / Hermance, Meghan; Thangamani, Saravanan.

In: Viruses, Vol. 10, No. 7, 362, 01.07.2018.

Research output: Contribution to journalReview article

Hermance, Meghan ; Thangamani, Saravanan. / Tick–virus–host interactions at the cutaneous interface : The nidus of flavivirus transmission. In: Viruses. 2018 ; Vol. 10, No. 7.
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