Tie2 Agonists Downregulate Angiopoietin-2 Production

S. Tsigkos, Z. Zhou, O. Roussos, A. Papapetropoulos

Research output: Contribution to journalArticlepeer-review


Angiopoietin-2 (Ang2) belongs to a novel family of angiogenic growth factors that also includes Ang-1, Ang-3 and Ang-4. Ang-2 binds to Tie2 receptors that are expressed on endothelial cells and inhibits Ang-1-induced receptor phosphorylation. Herein, we describe the effect of the Tie2 agonists Ang1 and Ang4, on Ang2 production by endothelial cells. We have shown that Ang1 and Ang4 inhibit Ang2 production in a PI3Kinase/Akt independent manner.

Original languageEnglish (US)
Pages (from-to)179-181
Number of pages3
JournalReview of Clinical Pharmacology and Pharmacokinetics, International Edition
Issue number1
StatePublished - 2004

ASJC Scopus subject areas

  • Pharmacology (medical)


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