Time course of Δ9-tetrahydrocannabinol inhibition of predatory aggression

M. Marlyne Kilbey, Kenneth M. Johnson, David M. McLendon

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Three studies assessed the time course of inhibition of predatory aggression and changes in levels of brain serotonin following administration of Δ9-THC. In Study One, six groups of six rats each were administered 1.25 mg/kg Δ9-THC IV and frog-killing behavior was measured at six postinjection intervals: 30, 60, 90, 150, 210, and 270 minutes. In Study Two, four groups of six rats each were tested. Group One received a vehicle control injection and was tested immediately, i.e. zero-minutes, postinjection. The remaining groups received 1.25 mg/kg Δ9-THC, and behavior was measured at 0, 15, and 30 min postinjection. In Study Three, two groups of six rats were treated with the vehicle or 1.25 mg/kg Δ9-THC and sacrificed one minute postinjection. Additional drug groups were sacrificed at 30 and 210 min postinjection. Levels of 5-HT were determined in four brain sections: cortex, midbrain, medulla, and cerebellum. Significant inhibition of predatory aggression was found for groups tested at 0, 15, and 30 min postinjection. Brain levels of 5-HT in the midbrain and/or medulla were significantly increased over the same period.

Original languageEnglish (US)
Pages (from-to)117-120
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume7
Issue number2
DOIs
StatePublished - Aug 1977

Keywords

  • Duration of effect
  • Medulla
  • Midbrain
  • Predatory agression
  • Serotonin
  • Δ-Tetrahydrocannabinol

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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