Time course of alterations in lung lymph and bronchial blood flows after inhalation injury

S. Abdi, David Herndon, J. McGuire, L. Traber, D. L. Traber

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The effects of inhalation injury on the pulmonary microvascular fluid flux and bronchial blood flow were examined in a long-term study of sheep (N = 13). They were insufflated with either 48 breaths of cotton smoke (n = 8) or air (n = 5) while they were deeply anesthetized with halothane. After injury, anesthesia was discontinued and the animals were mechanically ventilated throughout the experimental period (24 hours). Bronchial blood flow increased significantly at all time points recorded and reached its peak 20 minutes after the inhalation trauma (11 ± 1 ml/hr to 106 ± 18 ml/hr; p < 0.05). Thereafter, bronchial blood flow decreased to a value that was six to eight times above the baseline measurement for the remainder of the study period. With these changes in blood flow, there was a concomitant increase in lung lymph flow. This variable gradually increased and was 633% of the baseline value (6 ± 1 ml/hr to 44 ± 8 ml/hr) 24 hours after the challenge with smoke. The control animals showed little or no change in cardiopulmonary function during the experimental period. There is no correlation between the increase in bronchial blood flow and lung lymph flow patterns after cotton smoke inhalation injury.

Original languageEnglish (US)
Pages (from-to)510-515
Number of pages6
JournalJournal of Burn Care and Rehabilitation
Volume11
Issue number6
DOIs
StatePublished - 1990

Fingerprint

Lymph
Inhalation
Lung
Wounds and Injuries
Smoke
Smoke Inhalation Injury
Lung Injury
Halothane
Sheep
Anesthesia
Air

ASJC Scopus subject areas

  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)
  • Emergency Medicine

Cite this

Time course of alterations in lung lymph and bronchial blood flows after inhalation injury. / Abdi, S.; Herndon, David; McGuire, J.; Traber, L.; Traber, D. L.

In: Journal of Burn Care and Rehabilitation, Vol. 11, No. 6, 1990, p. 510-515.

Research output: Contribution to journalArticle

Abdi, S. ; Herndon, David ; McGuire, J. ; Traber, L. ; Traber, D. L. / Time course of alterations in lung lymph and bronchial blood flows after inhalation injury. In: Journal of Burn Care and Rehabilitation. 1990 ; Vol. 11, No. 6. pp. 510-515.
@article{1bc552d0c96e4d96a04011fdd24d4c27,
title = "Time course of alterations in lung lymph and bronchial blood flows after inhalation injury",
abstract = "The effects of inhalation injury on the pulmonary microvascular fluid flux and bronchial blood flow were examined in a long-term study of sheep (N = 13). They were insufflated with either 48 breaths of cotton smoke (n = 8) or air (n = 5) while they were deeply anesthetized with halothane. After injury, anesthesia was discontinued and the animals were mechanically ventilated throughout the experimental period (24 hours). Bronchial blood flow increased significantly at all time points recorded and reached its peak 20 minutes after the inhalation trauma (11 ± 1 ml/hr to 106 ± 18 ml/hr; p < 0.05). Thereafter, bronchial blood flow decreased to a value that was six to eight times above the baseline measurement for the remainder of the study period. With these changes in blood flow, there was a concomitant increase in lung lymph flow. This variable gradually increased and was 633{\%} of the baseline value (6 ± 1 ml/hr to 44 ± 8 ml/hr) 24 hours after the challenge with smoke. The control animals showed little or no change in cardiopulmonary function during the experimental period. There is no correlation between the increase in bronchial blood flow and lung lymph flow patterns after cotton smoke inhalation injury.",
author = "S. Abdi and David Herndon and J. McGuire and L. Traber and Traber, {D. L.}",
year = "1990",
doi = "10.1097/00004630-199011000-00005",
language = "English (US)",
volume = "11",
pages = "510--515",
journal = "Journal of Burn Care and Research",
issn = "1559-047X",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Time course of alterations in lung lymph and bronchial blood flows after inhalation injury

AU - Abdi, S.

AU - Herndon, David

AU - McGuire, J.

AU - Traber, L.

AU - Traber, D. L.

PY - 1990

Y1 - 1990

N2 - The effects of inhalation injury on the pulmonary microvascular fluid flux and bronchial blood flow were examined in a long-term study of sheep (N = 13). They were insufflated with either 48 breaths of cotton smoke (n = 8) or air (n = 5) while they were deeply anesthetized with halothane. After injury, anesthesia was discontinued and the animals were mechanically ventilated throughout the experimental period (24 hours). Bronchial blood flow increased significantly at all time points recorded and reached its peak 20 minutes after the inhalation trauma (11 ± 1 ml/hr to 106 ± 18 ml/hr; p < 0.05). Thereafter, bronchial blood flow decreased to a value that was six to eight times above the baseline measurement for the remainder of the study period. With these changes in blood flow, there was a concomitant increase in lung lymph flow. This variable gradually increased and was 633% of the baseline value (6 ± 1 ml/hr to 44 ± 8 ml/hr) 24 hours after the challenge with smoke. The control animals showed little or no change in cardiopulmonary function during the experimental period. There is no correlation between the increase in bronchial blood flow and lung lymph flow patterns after cotton smoke inhalation injury.

AB - The effects of inhalation injury on the pulmonary microvascular fluid flux and bronchial blood flow were examined in a long-term study of sheep (N = 13). They were insufflated with either 48 breaths of cotton smoke (n = 8) or air (n = 5) while they were deeply anesthetized with halothane. After injury, anesthesia was discontinued and the animals were mechanically ventilated throughout the experimental period (24 hours). Bronchial blood flow increased significantly at all time points recorded and reached its peak 20 minutes after the inhalation trauma (11 ± 1 ml/hr to 106 ± 18 ml/hr; p < 0.05). Thereafter, bronchial blood flow decreased to a value that was six to eight times above the baseline measurement for the remainder of the study period. With these changes in blood flow, there was a concomitant increase in lung lymph flow. This variable gradually increased and was 633% of the baseline value (6 ± 1 ml/hr to 44 ± 8 ml/hr) 24 hours after the challenge with smoke. The control animals showed little or no change in cardiopulmonary function during the experimental period. There is no correlation between the increase in bronchial blood flow and lung lymph flow patterns after cotton smoke inhalation injury.

UR - http://www.scopus.com/inward/record.url?scp=0025641679&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025641679&partnerID=8YFLogxK

U2 - 10.1097/00004630-199011000-00005

DO - 10.1097/00004630-199011000-00005

M3 - Article

VL - 11

SP - 510

EP - 515

JO - Journal of Burn Care and Research

JF - Journal of Burn Care and Research

SN - 1559-047X

IS - 6

ER -