Time course of hypoxic pulmonary vasoconstriction after endotoxin infusion in unanesthetized sheep

J. L. Theissen, H. M. Loick, B. B. Curry, L. D. Traber, David Herndon, D. L. Traber

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Endotoxin [lipopolysaccharide (LPS)] has been reported to reduce hypoxic pulmonary vasoconstriction and thus increases venous admixture. The time course of this failure of pulmonary blood flow regulation was investigated in six chronically instrumented unanesthetized sheep after infusion of Escherichia coli LPS (1 μg/kg). The change in left pulmonary arterial blood flow (LPBF, ultrasonic transit time) in response to unilateral lung hypoxia (10 min of N2 alternately to the left and right lungs) was compared before and at various time intervals after the administration of LPS. During baseline conditions, LPBF was 33% of total cardiac output and decreased to 15% when the left lung was ventilated with a hypoxic gas mixture. One hour after endotoxin infusion, LPBF remained at 33% of total cardiac output yet only decreased to 28% during the hypoxic challenge. The response to one-lung hypoxia was still significantly depressed 10 h post-LPS administration. It is concluded that hypoxic pulmonary vasoconstriction is almost completely abolished for a prolonged time period after a small dose of LPS.

Original languageEnglish (US)
Pages (from-to)2120-2125
Number of pages6
JournalJournal of Applied Physiology
Volume70
Issue number5
StatePublished - 1991

Fingerprint

Vasoconstriction
Endotoxins
Sheep
Lung
Lipopolysaccharides
Cardiac Output
Ultrasonics
Escherichia coli

Keywords

  • hemodynamics
  • pulmonary blood flow
  • separate lung ventilation
  • sepsis
  • ultrasonic blood flow measurement

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Theissen, J. L., Loick, H. M., Curry, B. B., Traber, L. D., Herndon, D., & Traber, D. L. (1991). Time course of hypoxic pulmonary vasoconstriction after endotoxin infusion in unanesthetized sheep. Journal of Applied Physiology, 70(5), 2120-2125.

Time course of hypoxic pulmonary vasoconstriction after endotoxin infusion in unanesthetized sheep. / Theissen, J. L.; Loick, H. M.; Curry, B. B.; Traber, L. D.; Herndon, David; Traber, D. L.

In: Journal of Applied Physiology, Vol. 70, No. 5, 1991, p. 2120-2125.

Research output: Contribution to journalArticle

Theissen, JL, Loick, HM, Curry, BB, Traber, LD, Herndon, D & Traber, DL 1991, 'Time course of hypoxic pulmonary vasoconstriction after endotoxin infusion in unanesthetized sheep', Journal of Applied Physiology, vol. 70, no. 5, pp. 2120-2125.
Theissen JL, Loick HM, Curry BB, Traber LD, Herndon D, Traber DL. Time course of hypoxic pulmonary vasoconstriction after endotoxin infusion in unanesthetized sheep. Journal of Applied Physiology. 1991;70(5):2120-2125.
Theissen, J. L. ; Loick, H. M. ; Curry, B. B. ; Traber, L. D. ; Herndon, David ; Traber, D. L. / Time course of hypoxic pulmonary vasoconstriction after endotoxin infusion in unanesthetized sheep. In: Journal of Applied Physiology. 1991 ; Vol. 70, No. 5. pp. 2120-2125.
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