Tissue engineered fetal skin constructs for pediatric burns

William Norbury, Mark G. Jeschke, David Herndon

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The management of patients with partial thickness (second degree) burns is problematic due to the different treatments needed for varying depths of injury. A report recently published in The Lancet describes a novel treatment for deep second degree burns using a fetal skin construct (FSC). The authors included eight pediatric patients with small second degree burns. They showed that FSCs reduced the need for autografting of deep second degree burns, with little hypertrophy of new skin and no skin contraction. This technology is new and exciting, but in our opinion several issues must be addressed before FSCs can enter the clinical arena. All of the patients were included in the treatment group, and therefore no comparison with conventional skin substitutes was possible. There is no mention of the use of laser Doppler in any initial assessment of patients. The debridement carried out before application of the FSC is not elaborated upon, and the surface areas involved in the study were very small in most cases, which limits the relevance to patients with larger burns. The use of FSCs gives us an additional option in a range of possible treatments for this notoriously difficult-to-treat patient group.

Original languageEnglish (US)
Pages (from-to)533-534
Number of pages2
JournalCritical Care
Volume9
Issue number6
DOIs
StatePublished - Dec 2005

Fingerprint

Burns
Fetus
Pediatrics
Skin
Artificial Skin
Autologous Transplantation
Debridement
Therapeutics
Hypertrophy
Lasers
Technology
Wounds and Injuries

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Tissue engineered fetal skin constructs for pediatric burns. / Norbury, William; Jeschke, Mark G.; Herndon, David.

In: Critical Care, Vol. 9, No. 6, 12.2005, p. 533-534.

Research output: Contribution to journalArticle

Norbury, William ; Jeschke, Mark G. ; Herndon, David. / Tissue engineered fetal skin constructs for pediatric burns. In: Critical Care. 2005 ; Vol. 9, No. 6. pp. 533-534.
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