Tissue oxygen saturation during hyperthermic progressive central hypovolemia

Zachary J. Schlader, Eric Rivas, Babs R. Soller, Victor A. Convertino, Craig G. Crandall

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

During nor-mothermia, a reduction in near-infrared spectroscopy (NIRS)-derived tissue oxygen saturation (So2) is an indicator of central hypovolemia. Hyperthermia increases skin blood flow and reduces tolerance to central hypovolemia, both of which may alter the interpretation of tissue So2 during central hypovolemia. This study tested the hypothesis that maximal reductions in tissue SO2 would be similar throughout normothermic and hyperthermic central hypovolemia to presyncope. Ten healthy males (means ± SD; 32 ± 5 yr) underwent central hypovolemia via progressive lower-body negative pressure (LBNP) to presyncope during normothermia (skin temperature ≈ 34°C) and hyperthermia (+ 1.2 ± 0.1°C increase in internal temperature via a water-perfused suit, skin temperature ≈ 39°C). NIRS-derived forearm (flexor digitorum profundus) tissue So2 was measured throughout and analyzed as the absolute change from pre-LBNP. Hyperthermia reduced (P < 0.001) LBNP tolerance by 49 ± 33% (from 16.7 ± 7.9 to 7.2 ± 3.9 min). Pre-LBNP, tissue SO2 was similar (P = 0.654) between normothermia (74 ± 5%) and hyperthermia (73 ± 7%). Tissue SO2 decreased (P < 0.001) throughout LBNP, but the reduction from pre-LBNP to presyncope was greater during normothermia (— 10 ± 6%) than during hyperthermia (— 6 ± 5%; P = 0.041). Contrary to our hypothesis, these findings indicate that hyperthermia is associated with a smaller maximal reduction in tissue So2 during central hypovolemia to presyncope.

Original languageEnglish (US)
Pages (from-to)R731-R736
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume307
Issue number6
DOIs
StatePublished - Sep 15 2014
Externally publishedYes

Fingerprint

Hypovolemia
Lower Body Negative Pressure
Oxygen
Fever
Syncope
Near-Infrared Spectroscopy
Skin Temperature
Central Tolerance
Forearm
Skin
Temperature
Water

Keywords

  • Heat stress
  • Lower body negative pressure
  • Simulated hemorrhage
  • Syncope

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Medicine(all)

Cite this

Tissue oxygen saturation during hyperthermic progressive central hypovolemia. / Schlader, Zachary J.; Rivas, Eric; Soller, Babs R.; Convertino, Victor A.; Crandall, Craig G.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 307, No. 6, 15.09.2014, p. R731-R736.

Research output: Contribution to journalArticle

Schlader, Zachary J. ; Rivas, Eric ; Soller, Babs R. ; Convertino, Victor A. ; Crandall, Craig G. / Tissue oxygen saturation during hyperthermic progressive central hypovolemia. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2014 ; Vol. 307, No. 6. pp. R731-R736.
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abstract = "During nor-mothermia, a reduction in near-infrared spectroscopy (NIRS)-derived tissue oxygen saturation (So2) is an indicator of central hypovolemia. Hyperthermia increases skin blood flow and reduces tolerance to central hypovolemia, both of which may alter the interpretation of tissue So2 during central hypovolemia. This study tested the hypothesis that maximal reductions in tissue SO2 would be similar throughout normothermic and hyperthermic central hypovolemia to presyncope. Ten healthy males (means ± SD; 32 ± 5 yr) underwent central hypovolemia via progressive lower-body negative pressure (LBNP) to presyncope during normothermia (skin temperature ≈ 34°C) and hyperthermia (+ 1.2 ± 0.1°C increase in internal temperature via a water-perfused suit, skin temperature ≈ 39°C). NIRS-derived forearm (flexor digitorum profundus) tissue So2 was measured throughout and analyzed as the absolute change from pre-LBNP. Hyperthermia reduced (P < 0.001) LBNP tolerance by 49 ± 33{\%} (from 16.7 ± 7.9 to 7.2 ± 3.9 min). Pre-LBNP, tissue SO2 was similar (P = 0.654) between normothermia (74 ± 5{\%}) and hyperthermia (73 ± 7{\%}). Tissue SO2 decreased (P < 0.001) throughout LBNP, but the reduction from pre-LBNP to presyncope was greater during normothermia (— 10 ± 6{\%}) than during hyperthermia (— 6 ± 5{\%}; P = 0.041). Contrary to our hypothesis, these findings indicate that hyperthermia is associated with a smaller maximal reduction in tissue So2 during central hypovolemia to presyncope.",
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AB - During nor-mothermia, a reduction in near-infrared spectroscopy (NIRS)-derived tissue oxygen saturation (So2) is an indicator of central hypovolemia. Hyperthermia increases skin blood flow and reduces tolerance to central hypovolemia, both of which may alter the interpretation of tissue So2 during central hypovolemia. This study tested the hypothesis that maximal reductions in tissue SO2 would be similar throughout normothermic and hyperthermic central hypovolemia to presyncope. Ten healthy males (means ± SD; 32 ± 5 yr) underwent central hypovolemia via progressive lower-body negative pressure (LBNP) to presyncope during normothermia (skin temperature ≈ 34°C) and hyperthermia (+ 1.2 ± 0.1°C increase in internal temperature via a water-perfused suit, skin temperature ≈ 39°C). NIRS-derived forearm (flexor digitorum profundus) tissue So2 was measured throughout and analyzed as the absolute change from pre-LBNP. Hyperthermia reduced (P < 0.001) LBNP tolerance by 49 ± 33% (from 16.7 ± 7.9 to 7.2 ± 3.9 min). Pre-LBNP, tissue SO2 was similar (P = 0.654) between normothermia (74 ± 5%) and hyperthermia (73 ± 7%). Tissue SO2 decreased (P < 0.001) throughout LBNP, but the reduction from pre-LBNP to presyncope was greater during normothermia (— 10 ± 6%) than during hyperthermia (— 6 ± 5%; P = 0.041). Contrary to our hypothesis, these findings indicate that hyperthermia is associated with a smaller maximal reduction in tissue So2 during central hypovolemia to presyncope.

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KW - Simulated hemorrhage

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