Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy

David M. Asmuth; Corbin G. Thompson; Tae Wook Chun; Zhong Min Ma; Surinder Mann; Talia Sainz; Sergio Serrano-Villar; Netanya S. Utay; Juan Carlos Garcia; Paolo Troia-Cancio; Richard B. Pollard; Christopher J. Miller; Alan Landay; Angela D. Kashuba

doi:10.1093/infdis/jix418

Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy

David M. Asmuth, Corbin G. Thompson, Tae Wook Chun, Zhong Min Ma, Surinder Mann, Talia Sainz, Sergio Serrano-Villar, Netanya S. Utay, Juan Carlos Garcia, Paolo Troia-Cancio, Richard B. Pollard, Christopher J. Miller, Alan Landay, Angela D. Kashuba

Internal Medicine

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11 Scopus citations

Abstract

Plasma, duodenal, and rectal tissue antiretroviral therapy (ART) drug concentrations, human immunodeficiency virus (HIV) RNA and HIV DNA copy numbers, and recovery of mucosal immunity were measured before and 9 months after initiation of 3 different ART regimens in 26 subjects. Plasma and tissue HIV RNA correlated at baseline and when 9-month declines were compared, suggesting that these compartments are tightly associated. Antiretroviral tissue:blood penetration ratios were above the 50% inhibitory concentration values in almost 100% of cases. There were no correlations between drug concentrations and HIV DNA/RNA. Importantly, no evidence was found for residual viral replication or deficient tissue drug penetration to account for delayed gastrointestinal-associated lymphoid tissue immune recovery.

Original language	English (US)
Pages (from-to)	813-818
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	216
Issue number	7
DOIs	https://doi.org/10.1093/infdis/jix418
State	Published - Nov 1 2017

Keywords

ART tissue penetration
HIV persistence
antiretroviral concentration
gastrointestinal-associated lymphoid tissue
immune reconstitution

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jix418

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Asmuth, D. M., Thompson, C. G., Chun, T. W., Ma, Z. M., Mann, S., Sainz, T., Serrano-Villar, S., Utay, N. S., Garcia, J. C., Troia-Cancio, P., Pollard, R. B., Miller, C. J., Landay, A., & Kashuba, A. D. (2017). Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy. Journal of Infectious Diseases, 216(7), 813-818. https://doi.org/10.1093/infdis/jix418

Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy. / Asmuth, David M.; Thompson, Corbin G.; Chun, Tae Wook et al.
In: Journal of Infectious Diseases, Vol. 216, No. 7, 01.11.2017, p. 813-818.

Research output: Contribution to journal › Article › peer-review

Asmuth, DM, Thompson, CG, Chun, TW, Ma, ZM, Mann, S, Sainz, T, Serrano-Villar, S, Utay, NS, Garcia, JC, Troia-Cancio, P, Pollard, RB, Miller, CJ, Landay, A & Kashuba, AD 2017, 'Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy', Journal of Infectious Diseases, vol. 216, no. 7, pp. 813-818. https://doi.org/10.1093/infdis/jix418

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abstract = "Plasma, duodenal, and rectal tissue antiretroviral therapy (ART) drug concentrations, human immunodeficiency virus (HIV) RNA and HIV DNA copy numbers, and recovery of mucosal immunity were measured before and 9 months after initiation of 3 different ART regimens in 26 subjects. Plasma and tissue HIV RNA correlated at baseline and when 9-month declines were compared, suggesting that these compartments are tightly associated. Antiretroviral tissue:blood penetration ratios were above the 50% inhibitory concentration values in almost 100% of cases. There were no correlations between drug concentrations and HIV DNA/RNA. Importantly, no evidence was found for residual viral replication or deficient tissue drug penetration to account for delayed gastrointestinal-associated lymphoid tissue immune recovery.",

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AB - Plasma, duodenal, and rectal tissue antiretroviral therapy (ART) drug concentrations, human immunodeficiency virus (HIV) RNA and HIV DNA copy numbers, and recovery of mucosal immunity were measured before and 9 months after initiation of 3 different ART regimens in 26 subjects. Plasma and tissue HIV RNA correlated at baseline and when 9-month declines were compared, suggesting that these compartments are tightly associated. Antiretroviral tissue:blood penetration ratios were above the 50% inhibitory concentration values in almost 100% of cases. There were no correlations between drug concentrations and HIV DNA/RNA. Importantly, no evidence was found for residual viral replication or deficient tissue drug penetration to account for delayed gastrointestinal-associated lymphoid tissue immune recovery.

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Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy

Abstract

Keywords

ASJC Scopus subject areas

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