To ∼P or Not to ∼P? Non-canonical activation by two-component response regulators

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


Bacteria sense and respond to their environment through the use of two-component regulatory systems. The ability to adapt to a wide range of environmental stresses is directly related to the number of two-component systems an organism possesses. Recent advances in this area have identified numerous variations on the archetype systems that employ a sensor kinase and a response regulator. It is now evident that many orphan regulators that lack cognate kinases do not rely on phosphorylation for activation and new roles for unphosphorylated response regulators have been identified. The significance of recent findings and suggestions for further research are discussed.

Original languageEnglish (US)
Pages (from-to)203-213
Number of pages11
JournalMolecular Microbiology
Issue number2
StatePublished - Jan 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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