To Splice or Not to Splice, That Is the Treatment

Mariano A. Garcia-Blanco

doi:10.1016/j.chembiol.2020.12.002

To Splice or Not to Splice, That Is the Treatment

Mariano A. Garcia-Blanco

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In this issue of Cell Chemical Biology, Shibata et al. (2020) rescue expression of CFTR from a defective gene by inhibiting splicing factors required for the inclusion of a pathogenic pseudo exon. Their work highlights the untapped potential of RNA splicing as a therapeutic target.

Original language	English (US)
Pages (from-to)	1453-1455
Number of pages	3
Journal	Cell Chemical Biology
Volume	27
Issue number	12
DOIs	https://doi.org/10.1016/j.chembiol.2020.12.002
State	Published - Dec 17 2020
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

Access to Document

10.1016/j.chembiol.2020.12.002

Cite this

@article{39dcfcc04176459ea08d7e878f78feb2,

title = "To Splice or Not to Splice, That Is the Treatment",

abstract = "In this issue of Cell Chemical Biology, Shibata et al. (2020) rescue expression of CFTR from a defective gene by inhibiting splicing factors required for the inclusion of a pathogenic pseudo exon. Their work highlights the untapped potential of RNA splicing as a therapeutic target.",

author = "Garcia-Blanco, \{Mariano A.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = dec,

day = "17",

doi = "10.1016/j.chembiol.2020.12.002",

language = "English (US)",

volume = "27",

pages = "1453--1455",

journal = "Cell Chemical Biology",

issn = "2451-9456",

publisher = "Elsevier Inc.",

number = "12",

}

TY - JOUR

T1 - To Splice or Not to Splice, That Is the Treatment

AU - Garcia-Blanco, Mariano A.

PY - 2020/12/17

Y1 - 2020/12/17

N2 - In this issue of Cell Chemical Biology, Shibata et al. (2020) rescue expression of CFTR from a defective gene by inhibiting splicing factors required for the inclusion of a pathogenic pseudo exon. Their work highlights the untapped potential of RNA splicing as a therapeutic target.

AB - In this issue of Cell Chemical Biology, Shibata et al. (2020) rescue expression of CFTR from a defective gene by inhibiting splicing factors required for the inclusion of a pathogenic pseudo exon. Their work highlights the untapped potential of RNA splicing as a therapeutic target.

UR - https://www.scopus.com/pages/publications/85097741341

UR - https://www.scopus.com/inward/citedby.url?scp=85097741341&partnerID=8YFLogxK

U2 - 10.1016/j.chembiol.2020.12.002

DO - 10.1016/j.chembiol.2020.12.002

M3 - Comment/debate

C2 - 33338466

AN - SCOPUS:85097741341

SN - 2451-9456

VL - 27

SP - 1453

EP - 1455

JO - Cell Chemical Biology

JF - Cell Chemical Biology

IS - 12

ER -

To Splice or Not to Splice, That Is the Treatment

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this