Abstract
The family Togaviridae comprises four genera: Alphavirus (with 26 species), Rubivirus (one species), Pestivirus (three species), and Arterivirus (one species). The main characteristics of the member viruses are: (i) the virus particles are spherical, 50-70 nm in diameter, including an envelope with surface projections that incorporate two or three polypeptides, usually glycosylated; (ii) the nucleocapsid comprises a core protein and a single strand of positive-sense RNA, molecular weight about 4 x 106; where characterized, the RNA has an m7G 'cap' at the 5' end and is polyadenylated at the 3' end; (iii) maturation occurs by budding of spherical nucleocapsids 30-35 nm in diameter, with proven or presumed icosahedral symmetry, through cytoplasmic membranes. Where characterized, translation of structural proteins occurs on subgenomic messenger RNA(s); these appear to represent th 3' end of the genome. Nearly all alphavirus species are transmitted by mosquitoes. Transmission also occurs transovarially (Alphavirus) or transplacentally (Rubivirus and Pestvirus). Members of a genus are serologically related, but are not related to members of other genera.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 125-139 |
| Number of pages | 15 |
| Journal | Intervirology |
| Volume | 24 |
| Issue number | 3 |
| State | Published - 1985 |
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ASJC Scopus subject areas
- Virology
Cite this
Togaviridae. / Westaway, E. G.; Brinton, M. A.; Gaidamovich, S. Y.; Horzinek, M. C.; Igarashi, A.; Kääriäinen, L.; Lvov, D. K.; Porterfield, J. S.; Russell, P. K.; Trent, D. W.
In: Intervirology, Vol. 24, No. 3, 1985, p. 125-139.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Togaviridae
AU - Westaway, E. G.
AU - Brinton, M. A.
AU - Gaidamovich, S. Y.
AU - Horzinek, M. C.
AU - Igarashi, A.
AU - Kääriäinen, L.
AU - Lvov, D. K.
AU - Porterfield, J. S.
AU - Russell, P. K.
AU - Trent, D. W.
PY - 1985
Y1 - 1985
N2 - The family Togaviridae comprises four genera: Alphavirus (with 26 species), Rubivirus (one species), Pestivirus (three species), and Arterivirus (one species). The main characteristics of the member viruses are: (i) the virus particles are spherical, 50-70 nm in diameter, including an envelope with surface projections that incorporate two or three polypeptides, usually glycosylated; (ii) the nucleocapsid comprises a core protein and a single strand of positive-sense RNA, molecular weight about 4 x 106; where characterized, the RNA has an m7G 'cap' at the 5' end and is polyadenylated at the 3' end; (iii) maturation occurs by budding of spherical nucleocapsids 30-35 nm in diameter, with proven or presumed icosahedral symmetry, through cytoplasmic membranes. Where characterized, translation of structural proteins occurs on subgenomic messenger RNA(s); these appear to represent th 3' end of the genome. Nearly all alphavirus species are transmitted by mosquitoes. Transmission also occurs transovarially (Alphavirus) or transplacentally (Rubivirus and Pestvirus). Members of a genus are serologically related, but are not related to members of other genera.
AB - The family Togaviridae comprises four genera: Alphavirus (with 26 species), Rubivirus (one species), Pestivirus (three species), and Arterivirus (one species). The main characteristics of the member viruses are: (i) the virus particles are spherical, 50-70 nm in diameter, including an envelope with surface projections that incorporate two or three polypeptides, usually glycosylated; (ii) the nucleocapsid comprises a core protein and a single strand of positive-sense RNA, molecular weight about 4 x 106; where characterized, the RNA has an m7G 'cap' at the 5' end and is polyadenylated at the 3' end; (iii) maturation occurs by budding of spherical nucleocapsids 30-35 nm in diameter, with proven or presumed icosahedral symmetry, through cytoplasmic membranes. Where characterized, translation of structural proteins occurs on subgenomic messenger RNA(s); these appear to represent th 3' end of the genome. Nearly all alphavirus species are transmitted by mosquitoes. Transmission also occurs transovarially (Alphavirus) or transplacentally (Rubivirus and Pestvirus). Members of a genus are serologically related, but are not related to members of other genera.
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M3 - Article
VL - 24
SP - 125
EP - 139
JO - Intervirology
JF - Intervirology
SN - 0300-5526
IS - 3
ER -