Togaviridae

E. G. Westaway, M. A. Brinton, S. Y. Gaidamovich, M. C. Horzinek, A. Igarashi, L. Kääriäinen, D. K. Lvov, J. S. Porterfield, P. K. Russell, D. W. Trent

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

The family Togaviridae comprises four genera: Alphavirus (with 26 species), Rubivirus (one species), Pestivirus (three species), and Arterivirus (one species). The main characteristics of the member viruses are: (i) the virus particles are spherical, 50-70 nm in diameter, including an envelope with surface projections that incorporate two or three polypeptides, usually glycosylated; (ii) the nucleocapsid comprises a core protein and a single strand of positive-sense RNA, molecular weight about 4 x 106; where characterized, the RNA has an m7G 'cap' at the 5' end and is polyadenylated at the 3' end; (iii) maturation occurs by budding of spherical nucleocapsids 30-35 nm in diameter, with proven or presumed icosahedral symmetry, through cytoplasmic membranes. Where characterized, translation of structural proteins occurs on subgenomic messenger RNA(s); these appear to represent th 3' end of the genome. Nearly all alphavirus species are transmitted by mosquitoes. Transmission also occurs transovarially (Alphavirus) or transplacentally (Rubivirus and Pestvirus). Members of a genus are serologically related, but are not related to members of other genera.

Original languageEnglish (US)
Pages (from-to)125-139
Number of pages15
JournalIntervirology
Volume24
Issue number3
StatePublished - 1985

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Togaviridae
Alphavirus
Rubivirus
Nucleocapsid
Arterivirus
Pestivirus
RNA
Protein Biosynthesis
Culicidae
Virion
Molecular Weight
Cell Membrane
Genome
Viruses
Messenger RNA
Peptides
Proteins

ASJC Scopus subject areas

  • Virology

Cite this

Westaway, E. G., Brinton, M. A., Gaidamovich, S. Y., Horzinek, M. C., Igarashi, A., Kääriäinen, L., ... Trent, D. W. (1985). Togaviridae. Intervirology, 24(3), 125-139.

Togaviridae. / Westaway, E. G.; Brinton, M. A.; Gaidamovich, S. Y.; Horzinek, M. C.; Igarashi, A.; Kääriäinen, L.; Lvov, D. K.; Porterfield, J. S.; Russell, P. K.; Trent, D. W.

In: Intervirology, Vol. 24, No. 3, 1985, p. 125-139.

Research output: Contribution to journalArticle

Westaway, EG, Brinton, MA, Gaidamovich, SY, Horzinek, MC, Igarashi, A, Kääriäinen, L, Lvov, DK, Porterfield, JS, Russell, PK & Trent, DW 1985, 'Togaviridae', Intervirology, vol. 24, no. 3, pp. 125-139.
Westaway EG, Brinton MA, Gaidamovich SY, Horzinek MC, Igarashi A, Kääriäinen L et al. Togaviridae. Intervirology. 1985;24(3):125-139.
Westaway, E. G. ; Brinton, M. A. ; Gaidamovich, S. Y. ; Horzinek, M. C. ; Igarashi, A. ; Kääriäinen, L. ; Lvov, D. K. ; Porterfield, J. S. ; Russell, P. K. ; Trent, D. W. / Togaviridae. In: Intervirology. 1985 ; Vol. 24, No. 3. pp. 125-139.
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