Togavirus-associated pathologic changes in the midgut of a natural mosquito vector.

Scott Weaver, T. W. Scott, L. H. Lorenz, K. Lerdthusnee, W. S. Romoser

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Arthropod-borne viruses were not previously believed to cause discernible pathologic changes in their natural mosquito vectors. We report cytopathologic lesions in the midgut of the mosquito, Culiseta melanura, 2 to 5 days after oral infection with eastern equine encephalomyelitis virus. Sloughing of densely staining, heavily infected epithelial cells into the midgut lumen was observed by light and transmission electron microscopy, along with degeneration of cells within the epithelium. Pathological changes in midgut epithelial cells sometimes included loss of brush border and basal lamina integrity. Disruption of the midgut basal lamina could result in bypassing of barriers to virus dissemination within the mosquito and allow rapid transmission to occur. Alternatively, luminal sloughing of heavily infected midgut epithelial cells may serve to modulate mosquito infections. These findings challenge previous beliefs regarding the benign nature of arbovirus-invertebrate host relationships.

Original languageEnglish (US)
Pages (from-to)2083-2090
Number of pages8
JournalJournal of Virology
Volume62
Issue number6
StatePublished - Jun 1988
Externally publishedYes

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Togaviridae
Culicidae
midgut
Arboviruses
Epithelial Cells
Basement Membrane
Eastern equine encephalitis virus
arboviruses
epithelial cells
laminae (animals)
Invertebrates
Microvilli
Infection
Transmission Electron Microscopy
Culiseta melanura
Epithelium
Staining and Labeling
Viruses
Light
microvilli

ASJC Scopus subject areas

  • Immunology

Cite this

Weaver, S., Scott, T. W., Lorenz, L. H., Lerdthusnee, K., & Romoser, W. S. (1988). Togavirus-associated pathologic changes in the midgut of a natural mosquito vector. Journal of Virology, 62(6), 2083-2090.

Togavirus-associated pathologic changes in the midgut of a natural mosquito vector. / Weaver, Scott; Scott, T. W.; Lorenz, L. H.; Lerdthusnee, K.; Romoser, W. S.

In: Journal of Virology, Vol. 62, No. 6, 06.1988, p. 2083-2090.

Research output: Contribution to journalArticle

Weaver, S, Scott, TW, Lorenz, LH, Lerdthusnee, K & Romoser, WS 1988, 'Togavirus-associated pathologic changes in the midgut of a natural mosquito vector.', Journal of Virology, vol. 62, no. 6, pp. 2083-2090.
Weaver S, Scott TW, Lorenz LH, Lerdthusnee K, Romoser WS. Togavirus-associated pathologic changes in the midgut of a natural mosquito vector. Journal of Virology. 1988 Jun;62(6):2083-2090.
Weaver, Scott ; Scott, T. W. ; Lorenz, L. H. ; Lerdthusnee, K. ; Romoser, W. S. / Togavirus-associated pathologic changes in the midgut of a natural mosquito vector. In: Journal of Virology. 1988 ; Vol. 62, No. 6. pp. 2083-2090.
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