Toll-like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease

Brandie D. Taylor, Patricia A. Totten, Sabina G. Astete, Michael J. Ferris, David H. Martin, Roberta B. Ness, Catherine L. Haggerty

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Problem: Toll-like (TLR) receptor genetic variants have been implicated in bacterial vaginosis (BV). We determined whether TLR variants are associated with fastidious BV-associated microbes that are linked with infertility following pelvic inflammatory disease (PID). Method of study: Sneathia spp., Atopobium vaginae, BVAB1, and Ureaplasma urealyticum were measured in 250 women from the PID Evaluation and Clinical Health (PEACH) study. Relative risk (RR) and 95% confidence intervals (CI) were calculated adjusting for chlamydia and gonorrhea. Principal component analysis was used to adjust for population stratification. A false discovery rate q-value of 0.05 was significant. Results: TLR2-1733C>A (P =.003) and TLR2-616A>G (P =.004) were associated with cervical A. vaginae. TLR2-1733C>A and TLR6-438C>T were associated with A. vaginae detection in the endometrium, but this was not significant after adjustment for multiple comparisons (FDR q-value = 0.06). Conclusion: Host gene variants in TLR2 signaling pathways were modestly associated with cervical A. vaginae in women with clinical PID.

Original languageEnglish (US)
Article numbere12804
JournalAmerican Journal of Reproductive Immunology
Volume79
Issue number2
DOIs
StatePublished - Feb 2018
Externally publishedYes

Keywords

  • bacterial vaginosis
  • inflammation
  • pelvic inflammatory disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

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