Toll-like receptors, innate immunity and HSV pathogenesis

Melissa M. Herbst-Kralovetz, Richard Pyles

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

In the last decade, substantial progress has been made in understanding the molecular mechanisms involved in initial host responses to viral infections, and how viral recognition leads to the innate responses that ultimately shape the adaptive immune response. Viruses, including herpes simplex virus (HSV) types 1 and 2, trigger toll-like receptors (TLRs) that elicit cytokine and chemokine production. In turn, this can create local resistance and modulate T- and B-cell-mediated immunity. TLR activation by HSV-produced molecules (or other synthetic agonists) leads to the remodelling of draining lymph nodes. This enhances the screening of naïve T-cells, from which antigen-specific lymphocytes can be selected and expanded. The innate response thereby serves to direct a timely and effective acquired immune response, through the initial TLR recognition of viral pathogen-associated molecular patterns that can limit or possibly exacerbate viral pathogenesis. Recently, these findings have been exploited by strategies that utilize synthetic TLR agonists as prophylactic or therapeutic devices. Such devices prime innate immune responses, enhancing host resistance to viral infections, including experimental HSV infections.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalHerpes
Volume13
Issue number2
StatePublished - Aug 2006

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Toll-Like Receptors
Simplexvirus
Innate Immunity
Virus Diseases
Equipment and Supplies
Human Herpesvirus 2
Human Herpesvirus 1
Adaptive Immunity
Chemokines
Cellular Immunity
B-Lymphocytes
Lymph Nodes
Lymphocytes
Cytokines
Viruses
T-Lymphocytes
Antigens
Therapeutics

Keywords

  • Genital herpes
  • Herpes infections
  • Herpes simplex virus transmission
  • Innate immunity
  • Microbicide
  • TLR agonists
  • Toll-like receptors

ASJC Scopus subject areas

  • Virology
  • Dermatology

Cite this

Toll-like receptors, innate immunity and HSV pathogenesis. / Herbst-Kralovetz, Melissa M.; Pyles, Richard.

In: Herpes, Vol. 13, No. 2, 08.2006, p. 37-41.

Research output: Contribution to journalArticle

Herbst-Kralovetz, MM & Pyles, R 2006, 'Toll-like receptors, innate immunity and HSV pathogenesis', Herpes, vol. 13, no. 2, pp. 37-41.
Herbst-Kralovetz, Melissa M. ; Pyles, Richard. / Toll-like receptors, innate immunity and HSV pathogenesis. In: Herpes. 2006 ; Vol. 13, No. 2. pp. 37-41.
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