Tomographic needles and catheters for optical imaging of prostatic cancer

Steven L. Jacques, Massoud Motamedi

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations


Early detection of prostatic cancer currently depends on Prostate Serum Antigen (PSA) or TransRectal UltraSound (TRUS). Unfortunately, these techniques are not always reliable indicators for early small lesions still localized within the prostate. This paper presents a feasibility study on the use of "tomographic needles and catheters" for optical imaging of early lesions. Three needles are inserted perianeally into the prostate or two catheters are inserted into the rectal and urethral passages. Each contains a set of optical fibers which terminate at evenly spaced positions along the needle. Each termination serves as either a source or collector for light transmission as each fiber is sequentially illuminated. Application of a tomographic algorithm based on diffuse light transmission between each source/collector pair yields a fuzzy but spectrally informative image of the prostate. This paper addresses the issue of feasibility by asking whether such a technique can distinguish a large zone of slightly alter optical properties (essentially a region of normal tissue) from a small zone of strongly altered optical properties (a tumor). The paper simulates both steady-state and 3-GHz frequency-domain optical measurements.

Original languageEnglish (US)
Pages (from-to)111-118
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - May 12 1995
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems V 1995 - San Jose, United States
Duration: Feb 1 1995Feb 28 1995

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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