Topical nystatin powder in severe burns

A new treatment for angioinvasive fungal infections refractory to other topical and systemic agents

J. P. Barret, P. I. Ramzy, J. P. Heggers, C. Villareal, David Herndon, M. H. Desai

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Angioinvasive fungal infections have a significant morbidity and mortality in the immunocompromised host. Massive burns produce a profound derangement in cellular immunity along with a loss of cutaneous barrier function. Treatment of fungal burn wound infections poses a difficult therapeutic challenge. We present a new method of treatment for angioinvasive fungal infections with nystatin powder at a concentration of 6,000,000 units/g. It proved to be efficacious in four consecutive severely burned patients affected by massive angioinvasive fungal infection. Both superficial and deep tissue infections were eradicated without any other therapeutic interventions or adverse effects on wound healing.

Original languageEnglish (US)
Pages (from-to)505-508
Number of pages4
JournalBurns
Volume25
Issue number6
DOIs
StatePublished - Sep 1999

Fingerprint

Nystatin
Mycoses
Burns
Powders
Immunocompromised Host
Wound Infection
Therapeutics
Cellular Immunity
Wound Healing
Morbidity
Skin
Mortality
Infection

Keywords

  • Aspergillus
  • Burns
  • Fusarium
  • Nystatin

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

Cite this

Topical nystatin powder in severe burns : A new treatment for angioinvasive fungal infections refractory to other topical and systemic agents. / Barret, J. P.; Ramzy, P. I.; Heggers, J. P.; Villareal, C.; Herndon, David; Desai, M. H.

In: Burns, Vol. 25, No. 6, 09.1999, p. 505-508.

Research output: Contribution to journalArticle

Barret, J. P. ; Ramzy, P. I. ; Heggers, J. P. ; Villareal, C. ; Herndon, David ; Desai, M. H. / Topical nystatin powder in severe burns : A new treatment for angioinvasive fungal infections refractory to other topical and systemic agents. In: Burns. 1999 ; Vol. 25, No. 6. pp. 505-508.
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