Abstract
Angioinvasive fungal infections have a significant morbidity and mortality in the immunocompromised host. Massive burns produce a profound derangement in cellular immunity along with a loss of cutaneous barrier function. Treatment of fungal burn wound infections poses a difficult therapeutic challenge. We present a new method of treatment for angioinvasive fungal infections with nystatin powder at a concentration of 6,000,000 units/g. It proved to be efficacious in four consecutive severely burned patients affected by massive angioinvasive fungal infection. Both superficial and deep tissue infections were eradicated without any other therapeutic interventions or adverse effects on wound healing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 505-508 |
| Number of pages | 4 |
| Journal | Burns |
| Volume | 25 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 1999 |
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Keywords
- Aspergillus
- Burns
- Fusarium
- Nystatin
ASJC Scopus subject areas
- Emergency Medicine
- Surgery
Cite this
Topical nystatin powder in severe burns : A new treatment for angioinvasive fungal infections refractory to other topical and systemic agents. / Barret, J. P.; Ramzy, P. I.; Heggers, J. P.; Villareal, C.; Herndon, David; Desai, M. H.
In: Burns, Vol. 25, No. 6, 09.1999, p. 505-508.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Topical nystatin powder in severe burns
T2 - A new treatment for angioinvasive fungal infections refractory to other topical and systemic agents
AU - Barret, J. P.
AU - Ramzy, P. I.
AU - Heggers, J. P.
AU - Villareal, C.
AU - Herndon, David
AU - Desai, M. H.
PY - 1999/9
Y1 - 1999/9
N2 - Angioinvasive fungal infections have a significant morbidity and mortality in the immunocompromised host. Massive burns produce a profound derangement in cellular immunity along with a loss of cutaneous barrier function. Treatment of fungal burn wound infections poses a difficult therapeutic challenge. We present a new method of treatment for angioinvasive fungal infections with nystatin powder at a concentration of 6,000,000 units/g. It proved to be efficacious in four consecutive severely burned patients affected by massive angioinvasive fungal infection. Both superficial and deep tissue infections were eradicated without any other therapeutic interventions or adverse effects on wound healing.
AB - Angioinvasive fungal infections have a significant morbidity and mortality in the immunocompromised host. Massive burns produce a profound derangement in cellular immunity along with a loss of cutaneous barrier function. Treatment of fungal burn wound infections poses a difficult therapeutic challenge. We present a new method of treatment for angioinvasive fungal infections with nystatin powder at a concentration of 6,000,000 units/g. It proved to be efficacious in four consecutive severely burned patients affected by massive angioinvasive fungal infection. Both superficial and deep tissue infections were eradicated without any other therapeutic interventions or adverse effects on wound healing.
KW - Aspergillus
KW - Burns
KW - Fusarium
KW - Nystatin
UR - http://www.scopus.com/inward/record.url?scp=0032845488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032845488&partnerID=8YFLogxK
U2 - 10.1016/S0305-4179(99)00037-6
DO - 10.1016/S0305-4179(99)00037-6
M3 - Article
C2 - 10498358
AN - SCOPUS:0032845488
VL - 25
SP - 505
EP - 508
JO - Burns
JF - Burns
SN - 0305-4179
IS - 6
ER -