Topical nystatin powder in severe burns: A new treatment for angioinvasive fungal infections refractory to other topical and systemic agents

J. P. Barret; P. I. Ramzy; J. P. Heggers; C. Villareal; D. N. Herndon; M. H. Desai

doi:10.1016/S0305-4179(99)00037-6

Topical nystatin powder in severe burns: A new treatment for angioinvasive fungal infections refractory to other topical and systemic agents

J. P. Barret, P. I. Ramzy, J. P. Heggers, C. Villareal, D. N. Herndon, M. H. Desai

Surgery

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Angioinvasive fungal infections have a significant morbidity and mortality in the immunocompromised host. Massive burns produce a profound derangement in cellular immunity along with a loss of cutaneous barrier function. Treatment of fungal burn wound infections poses a difficult therapeutic challenge. We present a new method of treatment for angioinvasive fungal infections with nystatin powder at a concentration of 6,000,000 units/g. It proved to be efficacious in four consecutive severely burned patients affected by massive angioinvasive fungal infection. Both superficial and deep tissue infections were eradicated without any other therapeutic interventions or adverse effects on wound healing.

Original language	English (US)
Pages (from-to)	505-508
Number of pages	4
Journal	Burns
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/S0305-4179(99)00037-6
State	Published - Sep 1 1999

Keywords

Aspergillus
Burns
Fusarium
Nystatin

ASJC Scopus subject areas

Surgery
Emergency Medicine
Critical Care and Intensive Care Medicine

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title = "Topical nystatin powder in severe burns: A new treatment for angioinvasive fungal infections refractory to other topical and systemic agents",

abstract = "Angioinvasive fungal infections have a significant morbidity and mortality in the immunocompromised host. Massive burns produce a profound derangement in cellular immunity along with a loss of cutaneous barrier function. Treatment of fungal burn wound infections poses a difficult therapeutic challenge. We present a new method of treatment for angioinvasive fungal infections with nystatin powder at a concentration of 6,000,000 units/g. It proved to be efficacious in four consecutive severely burned patients affected by massive angioinvasive fungal infection. Both superficial and deep tissue infections were eradicated without any other therapeutic interventions or adverse effects on wound healing.",

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AU - Barret, J. P.

AU - Ramzy, P. I.

AU - Heggers, J. P.

AU - Villareal, C.

AU - Herndon, D. N.

AU - Desai, M. H.

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N2 - Angioinvasive fungal infections have a significant morbidity and mortality in the immunocompromised host. Massive burns produce a profound derangement in cellular immunity along with a loss of cutaneous barrier function. Treatment of fungal burn wound infections poses a difficult therapeutic challenge. We present a new method of treatment for angioinvasive fungal infections with nystatin powder at a concentration of 6,000,000 units/g. It proved to be efficacious in four consecutive severely burned patients affected by massive angioinvasive fungal infection. Both superficial and deep tissue infections were eradicated without any other therapeutic interventions or adverse effects on wound healing.

AB - Angioinvasive fungal infections have a significant morbidity and mortality in the immunocompromised host. Massive burns produce a profound derangement in cellular immunity along with a loss of cutaneous barrier function. Treatment of fungal burn wound infections poses a difficult therapeutic challenge. We present a new method of treatment for angioinvasive fungal infections with nystatin powder at a concentration of 6,000,000 units/g. It proved to be efficacious in four consecutive severely burned patients affected by massive angioinvasive fungal infection. Both superficial and deep tissue infections were eradicated without any other therapeutic interventions or adverse effects on wound healing.

KW - Aspergillus

KW - Burns

KW - Fusarium

KW - Nystatin

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Topical nystatin powder in severe burns: A new treatment for angioinvasive fungal infections refractory to other topical and systemic agents

Abstract

Keywords

ASJC Scopus subject areas

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