Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing ebola virus immune evasion

Keyphrases

• Anthracycline Antibiotics 20%
• Bioactive Compounds 20%
• Broad-spectrum Activity 20%
• Cancer Chemotherapeutics 20%
• Chemotherapy 20%
• Daunorubicin 20%
• DNA Biosensor 20%
• DNA Damage 100%
• DNA Damage Response 20%
• DNA Intercalation 20%
• DNA Sensing 20%
• Doxorubicin 60%
• Ebola Glycoprotein 20%
• Ebola Virus 100%
• High-throughput Screening Assays 20%
• Immune Antagonists 20%
• Immune Escape 20%
• Innate Immune Evasion 20%
• Innate Immune Response 20%
• Interferon Antagonist 40%
• Interferon Induction 60%
• Interferon Response 100%
• Interferon-beta (IFN-β) 40%
• Interferon-α (IFN-α) 20%
• Negative-sense RNA Virus 20%
• Novel Assay 20%
• Novel Therapeutics 20%
• Public Health Risk 20%
• Replication in Vitro 20%
• RIG-I-like Receptors 20%
• RNA Virus 60%
• RNA Virus Replication 20%
• Signaling Molecules 20%
• Signaling Pathway 20%
• Small Molecules 20%
• Stimulator of Interferon Genes (STING) 20%
• STING Pathway 40%
• Therapeutic Approaches 20%
• Therapeutic Interventions 20%
• Topoisomerase II 20%
• Topoisomerase Inhibitors 100%
• Viral 20%
• Viral Immune Evasion 100%
• Virus Pathogenesis 20%
• Virus Replication 40%
• VP35 40%
• Vulnerability 20%

Immunology and Microbiology

• Beta Interferon 16%
• DNA Damage 100%
• DNA Damage Response 16%
• Ebola Virus 100%
• High Throughput Screening 16%
• Immune Evasion 100%
• In Vitro 16%
• Infection 16%
• Infectious Disease 16%
• interferon 100%
• Interferon Alfa 16%
• Interferon Induction 50%
• Kinase 16%
• Negative-Strand RNA Virus 16%
• Phosphotransferase 16%
• RIG-I-like Receptor 16%
• RNA Virus 66%
• Signal Transduction 33%
• Viral Protein 16%
• Viral Replication 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Alpha Interferon 11%
• Anthracycline Antibiotic Agent 11%
• Antiinfective Agent 22%
• ATM Protein 11%
• Beta Interferon 11%
• Chemotherapy Regimens 11%
• Daunorubicin 11%
• DNA Topoisomerase (ATP Hydrolysing) 11%
• Doxorubicin 33%
• Ebola Virus 100%
• Gyrase Inhibitor 100%
• High-Throughput Screening 11%
• Infection 11%
• Intercalating Agent 11%
• Interferon 100%
• Malignant Neoplasm 11%
• Negative-Strand RNA Virus 11%
• Pathogenesis 11%
• Receptor 11%
• RNA Virus 44%
• Viral Protein 11%
• Virus 11%