TY - JOUR
T1 - Torsional injury resulting in disc degeneration
T2 - I. An in vivo rabbit model
AU - Hadjipavlou, Alexander G.
AU - Simmons, James W.
AU - Yang, Jinping P.
AU - Bi, Lin Xiang
AU - Ansari, Ghulam A.S.
AU - Kaphalia, Bhupendra S.
AU - Simmons, David J.
AU - Nicodemus, Clarence L.
AU - Necessary, Jeffrey T.
AU - Lane, Richard
AU - Esch, Oliver
PY - 1998
Y1 - 1998
N2 - Torsional injuries may be a precursor to intervertebral disc degeneration, but published rabbit models indicate a latent time of 6 months. We describe a rabbit model in which instability and disc degeneration appear within 3 months. Sixty-five male New Zealand rabbits underwent presurgical irradiation to inhibit heterotopic bone formation. Control animals then underwent either a soft-tissue release or facetectomy and capsulotomy, whereas experimental animals received surgery and an acute 30°torsional lumbar injury. Capsulotomy, as well as facetectomy without torsion, failed to effect disc degeneration. However, the rabbits that received torsion exhibited clear indications of degenerative disc changes (thinning, increased PLA2 levels, and decreased nucleus pulposus volume) within 60-90 days. The observations associate disc degeneration with a destabilizing acute torsional injury.
AB - Torsional injuries may be a precursor to intervertebral disc degeneration, but published rabbit models indicate a latent time of 6 months. We describe a rabbit model in which instability and disc degeneration appear within 3 months. Sixty-five male New Zealand rabbits underwent presurgical irradiation to inhibit heterotopic bone formation. Control animals then underwent either a soft-tissue release or facetectomy and capsulotomy, whereas experimental animals received surgery and an acute 30°torsional lumbar injury. Capsulotomy, as well as facetectomy without torsion, failed to effect disc degeneration. However, the rabbits that received torsion exhibited clear indications of degenerative disc changes (thinning, increased PLA2 levels, and decreased nucleus pulposus volume) within 60-90 days. The observations associate disc degeneration with a destabilizing acute torsional injury.
KW - Intervertebral disc degeneration
KW - Lumbar spine
KW - Phospholipase A
KW - Torsional injury
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M3 - Article
C2 - 9726300
AN - SCOPUS:0031874472
SN - 0895-0385
VL - 11
SP - 312
EP - 317
JO - Journal of Spinal Disorders
JF - Journal of Spinal Disorders
IS - 4
ER -