Total anticholinergic burden and survival within a cohort of elderly Mexican Americans

G. Blair Sarbacker, David V. Espino, Robert C. Wood, Sandra L. Oakes, Dheeraj Anand, Kyriakos Markides

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: Studies examining the association between mortality and anticholinergic burden in the geriatric population are conflicting and are absent in the Mexican American population. The present study aimed to determine whether higher anticholinergic burden increases mortality in a cohort representative of community-based older Mexican Americans in the USA. Methods: This retrospective cohort database study used the Hispanic Established Populations for the Epidemiologic Study of the Elderly cohort. The primary outcome, mortality, was assessed beginning at the second interview in 1995 until the fifth interview in 2005. Medications were classified for anticholinergic burden according to the modified-Anticholinergic Drug Scale and were summed across all reported medications creating a measure of total anticholinergic burden. Anticholinergic burden was tested for association with mortality using survival analysis. Results: The 1497 older adults reporting medication usage were included. Survival analysis showed a statistically significant (P<0.05) relationship between anticholinergic burden and increased mortality. Conclusions: Anticholinergic burden is associated with increased mortality in Southwestern Mexican American older adults who report taking prescription or non prescription medications. These findings suggest that anticholinergic burden might be a risk factor for mortality in this selected population, with additional studies required to further define the risk. Geriatr Gerontol Int 2016; ••: ••-••.

Original languageEnglish (US)
JournalGeriatrics and Gerontology International
DOIs
StateAccepted/In press - 2016

Fingerprint

Cholinergic Antagonists
mortality
medication
Mortality
Survival Analysis
Population
Prescriptions
Interviews
geriatrics
interview
Hispanic Americans
Geriatrics
drug
Epidemiologic Studies
Cohort Studies
Databases
community

Keywords

  • Adverse drug event
  • Aged
  • Drug toxicity
  • Mexican American
  • Mortality

ASJC Scopus subject areas

  • Health(social science)
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Total anticholinergic burden and survival within a cohort of elderly Mexican Americans. / Sarbacker, G. Blair; Espino, David V.; Wood, Robert C.; Oakes, Sandra L.; Anand, Dheeraj; Markides, Kyriakos.

In: Geriatrics and Gerontology International, 2016.

Research output: Contribution to journalArticle

Sarbacker, G. Blair ; Espino, David V. ; Wood, Robert C. ; Oakes, Sandra L. ; Anand, Dheeraj ; Markides, Kyriakos. / Total anticholinergic burden and survival within a cohort of elderly Mexican Americans. In: Geriatrics and Gerontology International. 2016.
@article{a4c8cf7a7bbc44bf84cd9ffd6af0e28b,
title = "Total anticholinergic burden and survival within a cohort of elderly Mexican Americans",
abstract = "Aim: Studies examining the association between mortality and anticholinergic burden in the geriatric population are conflicting and are absent in the Mexican American population. The present study aimed to determine whether higher anticholinergic burden increases mortality in a cohort representative of community-based older Mexican Americans in the USA. Methods: This retrospective cohort database study used the Hispanic Established Populations for the Epidemiologic Study of the Elderly cohort. The primary outcome, mortality, was assessed beginning at the second interview in 1995 until the fifth interview in 2005. Medications were classified for anticholinergic burden according to the modified-Anticholinergic Drug Scale and were summed across all reported medications creating a measure of total anticholinergic burden. Anticholinergic burden was tested for association with mortality using survival analysis. Results: The 1497 older adults reporting medication usage were included. Survival analysis showed a statistically significant (P<0.05) relationship between anticholinergic burden and increased mortality. Conclusions: Anticholinergic burden is associated with increased mortality in Southwestern Mexican American older adults who report taking prescription or non prescription medications. These findings suggest that anticholinergic burden might be a risk factor for mortality in this selected population, with additional studies required to further define the risk. Geriatr Gerontol Int 2016; ••: ••-••.",
keywords = "Adverse drug event, Aged, Drug toxicity, Mexican American, Mortality",
author = "Sarbacker, {G. Blair} and Espino, {David V.} and Wood, {Robert C.} and Oakes, {Sandra L.} and Dheeraj Anand and Kyriakos Markides",
year = "2016",
doi = "10.1111/ggi.12907",
language = "English (US)",
journal = "Geriatrics and Gerontology International",
issn = "1447-0594",
publisher = "Japan Geriatrics Society",

}

TY - JOUR

T1 - Total anticholinergic burden and survival within a cohort of elderly Mexican Americans

AU - Sarbacker, G. Blair

AU - Espino, David V.

AU - Wood, Robert C.

AU - Oakes, Sandra L.

AU - Anand, Dheeraj

AU - Markides, Kyriakos

PY - 2016

Y1 - 2016

N2 - Aim: Studies examining the association between mortality and anticholinergic burden in the geriatric population are conflicting and are absent in the Mexican American population. The present study aimed to determine whether higher anticholinergic burden increases mortality in a cohort representative of community-based older Mexican Americans in the USA. Methods: This retrospective cohort database study used the Hispanic Established Populations for the Epidemiologic Study of the Elderly cohort. The primary outcome, mortality, was assessed beginning at the second interview in 1995 until the fifth interview in 2005. Medications were classified for anticholinergic burden according to the modified-Anticholinergic Drug Scale and were summed across all reported medications creating a measure of total anticholinergic burden. Anticholinergic burden was tested for association with mortality using survival analysis. Results: The 1497 older adults reporting medication usage were included. Survival analysis showed a statistically significant (P<0.05) relationship between anticholinergic burden and increased mortality. Conclusions: Anticholinergic burden is associated with increased mortality in Southwestern Mexican American older adults who report taking prescription or non prescription medications. These findings suggest that anticholinergic burden might be a risk factor for mortality in this selected population, with additional studies required to further define the risk. Geriatr Gerontol Int 2016; ••: ••-••.

AB - Aim: Studies examining the association between mortality and anticholinergic burden in the geriatric population are conflicting and are absent in the Mexican American population. The present study aimed to determine whether higher anticholinergic burden increases mortality in a cohort representative of community-based older Mexican Americans in the USA. Methods: This retrospective cohort database study used the Hispanic Established Populations for the Epidemiologic Study of the Elderly cohort. The primary outcome, mortality, was assessed beginning at the second interview in 1995 until the fifth interview in 2005. Medications were classified for anticholinergic burden according to the modified-Anticholinergic Drug Scale and were summed across all reported medications creating a measure of total anticholinergic burden. Anticholinergic burden was tested for association with mortality using survival analysis. Results: The 1497 older adults reporting medication usage were included. Survival analysis showed a statistically significant (P<0.05) relationship between anticholinergic burden and increased mortality. Conclusions: Anticholinergic burden is associated with increased mortality in Southwestern Mexican American older adults who report taking prescription or non prescription medications. These findings suggest that anticholinergic burden might be a risk factor for mortality in this selected population, with additional studies required to further define the risk. Geriatr Gerontol Int 2016; ••: ••-••.

KW - Adverse drug event

KW - Aged

KW - Drug toxicity

KW - Mexican American

KW - Mortality

UR - http://www.scopus.com/inward/record.url?scp=84995950943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84995950943&partnerID=8YFLogxK

U2 - 10.1111/ggi.12907

DO - 10.1111/ggi.12907

M3 - Article

C2 - 27726265

AN - SCOPUS:84995950943

JO - Geriatrics and Gerontology International

JF - Geriatrics and Gerontology International

SN - 1447-0594

ER -