Trabeculectomy with mitomycin C versus ahmed glaucoma implant with mitomycin C for treatment of pediatric aphakic glaucoma

Mohammad Pakravan, Nikkhah Homayoon, Yazdani Shahin, Baradaran Rafiei Ali Reza

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


PURPOSE: To compare trabeculectomy with mitomycin C (T+MMC) and Ahmed glaucoma implant with MMC (AGI+MMC) in treatment of aphakic glaucoma in children below 16 years of age. DESIGN: Randomized clinical trial. PARTICIPANTS: Subjects less than 16 years of age who had previously undergone anterior lensectomy and vitrectomy for treatment of congenital cataract with unresponsive aphakic glaucoma (at least on 2 medications) were allocated in 2 groups: trabeculectomy with MMC (group A, 15 eyes) and AGI (group B, 15 eyes). METHODS: Fifteen eyes in each group underwent T+MMC or AGI+MMC. Complete and qualified success were defined as 5≤intraocular pressure≤21 mm Hg without and with medication, respectively. MAIN OUTCOME MEASURES: Intraocular pressure, visual acuity, and complications. RESULTS: Complete and qualified success rates were 33.3% and 40% in T+MMC group versus 20% and 66.7% in AGI+MMC group, respectively (P=0.36). Mean follow-up was 14.8 and 13.1 months and complication rates were 40% and 26.7% (P=0.44), respectively. CONCLUSIONS: T+MMC and AGI+MMC are comparable in terms of success rate and complications in pediatric aphakic glaucoma. PRECIS: This randomized clinical trial demonstrated comparable safety and efficacy for MMC trabeculectomy and AGI in the treatment of pediatric aphakic glaucoma.

Original languageEnglish (US)
Pages (from-to)631-636
Number of pages6
JournalJournal of Glaucoma
Issue number7
StatePublished - Oct 2007
Externally publishedYes


  • Ahmed glaucoma implant
  • Aphakic glaucoma
  • Trabeculectomy

ASJC Scopus subject areas

  • Ophthalmology


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