@article{8494666bb259462383f6515377faf379,
title = "Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review",
abstract = "Neurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system. Globally, the number of people with an ND is dramatically increasing consistent with the fast aging of society and one of the common features of NDs is the abnormal aggregation of diverse proteins. Autophagy is the main process by which misfolded proteins and damaged organelles are removed from cells. It has been found that the impairment of autophagy is associated with many NDs, suggesting that autophagy has a vital role in the neurodegeneration process. Recently, more and more studies have reported that autophagy inducers display a protective role in different ND experimental models, suggesting that enhancement of autophagy could be a potential therapy for NDs. In this review, the evidence for beneficial effects of traditional Chinese medicine (TCM) regulate autophagy in the models of Alzheimer's disease (AD), Parkinson's disease (PD), and other NDs are presented and common autophagy-related mechanisms are identified. The results demonstrate that TCM which regulate autophagy are potential therapeutic candidates for ND treatment.",
keywords = "Autophagy, Neurodegenerative disease, Neuroprotection, Traditional Chinese medicine",
author = "Wang, {Zi Ying} and Jia Liu and Zhou Zhu and Su, {Cheng Fu} and Sreenivasmurthy, {Sravan Gopalkrishnashetty} and Ashok Iyaswamy and Lu, {Jia Hong} and Gang Chen and Song, {Ju Xian} and Min Li",
note = "Funding Information: This study was supported by the National Natural Science Foundation of China (NSFC-81703487, NSFC-81773926), the General Research Fund (HKBU12101417, HKBU12100618) and the Hong Kong Health and Medical Research Fund (HMRF17182541, HMRF17182551) from Hong Kong Government, Research Funds (JCYJ 20180302174028790, JCYJ20180507184656626) from Shenzhen Science and Technology Innovation Commission, and Research Funds (RC-IRCs/17-18/03, RC-IRCMS/19-20/H02) from Hong Kong Baptist University. The authors would like to thank Dr. Martha Dahlen for her English editing. Funding Information: This study was supported by the National Natural Science Foundation of China ( NSFC-81703487 , NSFC-81773926 ), the General Research Fund ( HKBU12101417 , HKBU12100618 ) and the Hong Kong Health and Medical Research Fund ( HMRF17182541 , HMRF17182551 ) from Hong Kong Government, Research Funds ( JCYJ 20180302174028790 , JCYJ20180507184656626 ) from Shenzhen Science and Technology Innovation Commission, and Research Funds ( RC-IRCs/17-18/03 , RC-IRCMS/19-20/H02 ) from Hong Kong Baptist University . The authors would like to thank Dr. Martha Dahlen for her English editing. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2021",
month = jan,
doi = "10.1016/j.biopha.2020.110968",
language = "English (US)",
volume = "133",
journal = "Biomedicine and Pharmacotherapy",
issn = "0753-3322",
publisher = "Elsevier Masson",
}