Traditional medicinal plants conferring protection against ovalbumin-induced asthma in experimental animals: A review

Shazalyana Azman, Mahendran Sekar, Srinivasa Reddy Bonam, Siew Hua Gan, Suzana Wahidin, Pei Teng Lum, Shivsharan B. Dhadde

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Asthma is a chronic inflammatory disease of the respiratory tract in which the numerous immune cells, including eosinophils, neutrophils, macrophages, T-lymphocytes, mast cells and epithelial lining play key roles. The numerous anti-asthmatic drugs are available in modern medicine to treat asthma, but they have several disadvantages, including side effects and the cost variations, which compromise treatment compliance. The literature review reveals that traditional herbal medicines have good potential as alternative treatment and management for asthma. However, communities hesitated to use the traditional herbal medicines due to lack of established mechanism of action about their anti-asthmatic poten-tial. The present review aimed to summarise the information stated in the literature about the potential effect of traditional medicinal plants (TMPs) conferring protection against ovalbu-min (OVA)-induced asthma model. The literature search was conducted in database like PubMed, Scopus, Google Scholar and ScienceDirect. After screening through the literature from 2011 to date, a total of 27 medicinal plants and two polyherbal extracts have been reported to be used as traditional herbal medicines and also utilised to be tested against OVA-induced asthma, were included. We found them to be an important alternative source of treatment for asthma, since some have comparable efficacies with drugs commonly used in the modern system against asthma. All the reported medicinal plants confirmed their traditional use against asthma or its related inflammation. The present review provides faith in traditional information and also offers new insight into the potential of natural products against asthma.

Original languageEnglish (US)
Pages (from-to)641-662
Number of pages22
JournalJournal of Asthma and Allergy
Volume14
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • Allergic asthma
  • Inflammation
  • Natural products
  • OVA-induced asthma
  • T-helper cells
  • Traditional medicinal plants

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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