Transcranial Doppler measurements in migraine and nitroglycerin headache

Mounzer Y. Kassab, Arshad Majid, Omid Bakhtar, Muhammad U. Farooq, Kamakshi Patel, Edward M. Bednarczyk

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The objective of this study was to examine the cerebral circulation during spontaneous migraine attacks and to compare changes to an experimental headache model induced by nitroglycerin (NTG) infusion. This prospective study was carried out in a tertiary care hospital on migraineurs with or without aura. Healthy volunteers served as controls. There were no interventions. Flow velocity (FV) and pulsatility index (PI) were measured in migraineurs between and during headache attacks. In controls, FV and PI of the middle cerebral arteries were performed at baseline and after each IV infusion of 0.125, 0.25 and 0.5 μg/kg/min of NTG. In migraineurs, a significant increase in the mean flow velocity (MFV) in the left vertebral artery (VA) and the PI of the right VA during spontaneous migraine headache was found. In controls, all FV significantly decreased after infusion of NTG. The NTG model produces expected and substantially different vascular effects than those seen with spontaneous migraine headache.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
JournalJournal of Headache and Pain
Volume8
Issue number5
DOIs
StatePublished - Oct 2007
Externally publishedYes

Fingerprint

Nitroglycerin
Migraine Disorders
Vertebral Artery
Headache
Cerebrovascular Circulation
Middle Cerebral Artery
Tertiary Healthcare
Tertiary Care Centers
Blood Vessels
Epilepsy
Healthy Volunteers
Theoretical Models
Prospective Studies

Keywords

  • Flow velocity
  • Headache
  • Migraine
  • Nitroglycerin
  • Pulsatility index
  • Transcranial Doppler

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Neuroscience(all)

Cite this

Kassab, M. Y., Majid, A., Bakhtar, O., Farooq, M. U., Patel, K., & Bednarczyk, E. M. (2007). Transcranial Doppler measurements in migraine and nitroglycerin headache. Journal of Headache and Pain, 8(5), 289-293. https://doi.org/10.1007/s10194-007-0413-8

Transcranial Doppler measurements in migraine and nitroglycerin headache. / Kassab, Mounzer Y.; Majid, Arshad; Bakhtar, Omid; Farooq, Muhammad U.; Patel, Kamakshi; Bednarczyk, Edward M.

In: Journal of Headache and Pain, Vol. 8, No. 5, 10.2007, p. 289-293.

Research output: Contribution to journalArticle

Kassab, MY, Majid, A, Bakhtar, O, Farooq, MU, Patel, K & Bednarczyk, EM 2007, 'Transcranial Doppler measurements in migraine and nitroglycerin headache', Journal of Headache and Pain, vol. 8, no. 5, pp. 289-293. https://doi.org/10.1007/s10194-007-0413-8
Kassab, Mounzer Y. ; Majid, Arshad ; Bakhtar, Omid ; Farooq, Muhammad U. ; Patel, Kamakshi ; Bednarczyk, Edward M. / Transcranial Doppler measurements in migraine and nitroglycerin headache. In: Journal of Headache and Pain. 2007 ; Vol. 8, No. 5. pp. 289-293.
@article{e0be5823ad4346b4ab748380e331fa27,
title = "Transcranial Doppler measurements in migraine and nitroglycerin headache",
abstract = "The objective of this study was to examine the cerebral circulation during spontaneous migraine attacks and to compare changes to an experimental headache model induced by nitroglycerin (NTG) infusion. This prospective study was carried out in a tertiary care hospital on migraineurs with or without aura. Healthy volunteers served as controls. There were no interventions. Flow velocity (FV) and pulsatility index (PI) were measured in migraineurs between and during headache attacks. In controls, FV and PI of the middle cerebral arteries were performed at baseline and after each IV infusion of 0.125, 0.25 and 0.5 μg/kg/min of NTG. In migraineurs, a significant increase in the mean flow velocity (MFV) in the left vertebral artery (VA) and the PI of the right VA during spontaneous migraine headache was found. In controls, all FV significantly decreased after infusion of NTG. The NTG model produces expected and substantially different vascular effects than those seen with spontaneous migraine headache.",
keywords = "Flow velocity, Headache, Migraine, Nitroglycerin, Pulsatility index, Transcranial Doppler",
author = "Kassab, {Mounzer Y.} and Arshad Majid and Omid Bakhtar and Farooq, {Muhammad U.} and Kamakshi Patel and Bednarczyk, {Edward M.}",
year = "2007",
month = "10",
doi = "10.1007/s10194-007-0413-8",
language = "English (US)",
volume = "8",
pages = "289--293",
journal = "Journal of Headache and Pain",
issn = "1129-2369",
publisher = "Springer-Verlag Italia",
number = "5",

}

TY - JOUR

T1 - Transcranial Doppler measurements in migraine and nitroglycerin headache

AU - Kassab, Mounzer Y.

AU - Majid, Arshad

AU - Bakhtar, Omid

AU - Farooq, Muhammad U.

AU - Patel, Kamakshi

AU - Bednarczyk, Edward M.

PY - 2007/10

Y1 - 2007/10

N2 - The objective of this study was to examine the cerebral circulation during spontaneous migraine attacks and to compare changes to an experimental headache model induced by nitroglycerin (NTG) infusion. This prospective study was carried out in a tertiary care hospital on migraineurs with or without aura. Healthy volunteers served as controls. There were no interventions. Flow velocity (FV) and pulsatility index (PI) were measured in migraineurs between and during headache attacks. In controls, FV and PI of the middle cerebral arteries were performed at baseline and after each IV infusion of 0.125, 0.25 and 0.5 μg/kg/min of NTG. In migraineurs, a significant increase in the mean flow velocity (MFV) in the left vertebral artery (VA) and the PI of the right VA during spontaneous migraine headache was found. In controls, all FV significantly decreased after infusion of NTG. The NTG model produces expected and substantially different vascular effects than those seen with spontaneous migraine headache.

AB - The objective of this study was to examine the cerebral circulation during spontaneous migraine attacks and to compare changes to an experimental headache model induced by nitroglycerin (NTG) infusion. This prospective study was carried out in a tertiary care hospital on migraineurs with or without aura. Healthy volunteers served as controls. There were no interventions. Flow velocity (FV) and pulsatility index (PI) were measured in migraineurs between and during headache attacks. In controls, FV and PI of the middle cerebral arteries were performed at baseline and after each IV infusion of 0.125, 0.25 and 0.5 μg/kg/min of NTG. In migraineurs, a significant increase in the mean flow velocity (MFV) in the left vertebral artery (VA) and the PI of the right VA during spontaneous migraine headache was found. In controls, all FV significantly decreased after infusion of NTG. The NTG model produces expected and substantially different vascular effects than those seen with spontaneous migraine headache.

KW - Flow velocity

KW - Headache

KW - Migraine

KW - Nitroglycerin

KW - Pulsatility index

KW - Transcranial Doppler

UR - http://www.scopus.com/inward/record.url?scp=36749086000&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36749086000&partnerID=8YFLogxK

U2 - 10.1007/s10194-007-0413-8

DO - 10.1007/s10194-007-0413-8

M3 - Article

C2 - 17955171

AN - SCOPUS:36749086000

VL - 8

SP - 289

EP - 293

JO - Journal of Headache and Pain

JF - Journal of Headache and Pain

SN - 1129-2369

IS - 5

ER -