Transcriptional regulation of hepatic angiotensinogen gene expression by the acute-phase response

David Ron, Allan R. Brasier, Joel F. Habener

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The acute-phase response is a protective physiological reaction to tissue injury manifested by the immediate increase in production and secretion of liver proteins the function of which is to re-establish the homeostasis altered by injury. Such proteins include blood coagulation factors, opsonins, protease-inhibitors and angiotensinogen, a precursor of the potent vasopressor peptide angiotensin II. The angiotensinogen gene is typical of genes regulated during the acute-phase response inasmuch as the promoter regulating its transcription rate is acutely responsive to three known mediators of the acute-phase response: glucocorticoids, and the cytokines interleukin-1 and tumor necrosis factor. We present a model, based on experimental evidence, for the mechanism by which angiotensinogen gene transcription is regulated in a graded fashion by the interplay of several hormonally-inducible transcription factors that bind a hormonally-inducible enhancer unit of the angiotensinogen promoter. These factors include the glucocorticoid receptor, nuclear factor kappa B and members of the CAAT/viral enhancer (C/EBP) family of DNA-binding proteins.

Original languageEnglish (US)
Pages (from-to)C97-C104
JournalMolecular and Cellular Endocrinology
Volume74
Issue number3
DOIs
StatePublished - Dec 21 1990

    Fingerprint

Keywords

  • Acute phase response
  • Angiotensinogen
  • Gene transcription
  • Glucocorticoids
  • Interleukin-1
  • Nuclear factor kB

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this