Transcriptional regulation of hepatic angiotensinogen gene expression by the acute-phase response

David Ron, Allan R. Brasier, Joel F. Habener

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The acute-phase response is a protective physiological reaction to tissue injury manifested by the immediate increase in production and secretion of liver proteins the function of which is to re-establish the homeostasis altered by injury. Such proteins include blood coagulation factors, opsonins, protease-inhibitors and angiotensinogen, a precursor of the potent vasopressor peptide angiotensin II. The angiotensinogen gene is typical of genes regulated during the acute-phase response inasmuch as the promoter regulating its transcription rate is acutely responsive to three known mediators of the acute-phase response: glucocorticoids, and the cytokines interleukin-1 and tumor necrosis factor. We present a model, based on experimental evidence, for the mechanism by which angiotensinogen gene transcription is regulated in a graded fashion by the interplay of several hormonally-inducible transcription factors that bind a hormonally-inducible enhancer unit of the angiotensinogen promoter. These factors include the glucocorticoid receptor, nuclear factor kappa B and members of the CAAT/viral enhancer (C/EBP) family of DNA-binding proteins.

Original languageEnglish (US)
JournalMolecular and Cellular Endocrinology
Volume74
Issue number3
DOIs
StatePublished - Dec 21 1990
Externally publishedYes

Fingerprint

Angiotensinogen
Acute-Phase Reaction
Gene expression
Gene Expression
Genes
Liver
Transcription
Opsonin Proteins
Blood Coagulation Factors
NF-kappa B
Glucocorticoid Receptors
Wounds and Injuries
DNA-Binding Proteins
Protease Inhibitors
Interleukin-1
Angiotensin II
Glucocorticoids
Proteins
Homeostasis
Transcription Factors

Keywords

  • Acute phase response
  • Angiotensinogen
  • Gene transcription
  • Glucocorticoids
  • Interleukin-1
  • Nuclear factor kB

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Transcriptional regulation of hepatic angiotensinogen gene expression by the acute-phase response. / Ron, David; Brasier, Allan R.; Habener, Joel F.

In: Molecular and Cellular Endocrinology, Vol. 74, No. 3, 21.12.1990.

Research output: Contribution to journalArticle

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