Transfected human β-polymerase promoter contains a ras-responsive element

P. S. Kedar, D. R. Lowy, S. G. Widen, S. H. Wilson

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21(v-ras(H)) expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.

Original languageEnglish (US)
Pages (from-to)3852-3856
Number of pages5
JournalMolecular and cellular biology
Volume10
Issue number7
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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