Transfected human β-polymerase promoter contains a ras-responsive element

P. S. Kedar; D. R. Lowy; S. G. Widen; S. H. Wilson

doi:10.1128/MCB.10.7.3852

Transfected human β-polymerase promoter contains a ras-responsive element

P. S. Kedar, D. R. Lowy, S. G. Widen, S. H. Wilson

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33 Scopus citations

Abstract

β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21(v-ras(H)) expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.

Original language	English (US)
Pages (from-to)	3852-3856
Number of pages	5
Journal	Molecular and cellular biology
Volume	10
Issue number	7
DOIs	https://doi.org/10.1128/MCB.10.7.3852
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1128/MCB.10.7.3852

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abstract = "β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21(v-ras(H)) expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.",

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year = "1990",

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AU - Lowy, D. R.

AU - Widen, S. G.

AU - Wilson, S. H.

PY - 1990

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AB - β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21(v-ras(H)) expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.

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Transfected human β-polymerase promoter contains a ras-responsive element

Abstract

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