Transfected human β-polymerase promoter contains a ras-responsive element

P. S. Kedar, D. R. Lowy, Steven Widen, S. H. Wilson

Research output: Contribution to journalArticle

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Abstract

β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21(v-ras(H)) expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.

Original languageEnglish (US)
Pages (from-to)3852-3856
Number of pages5
JournalMolecular and Cellular Biology
Volume10
Issue number7
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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