Transfected human β-polymerase promoter contains a ras-responsive element

P. S. Kedar, D. R. Lowy, Steven Widen, S. H. Wilson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21(v-ras(H)) expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.

Original languageEnglish (US)
Pages (from-to)3852-3856
Number of pages5
JournalMolecular and Cellular Biology
Volume10
Issue number7
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Oncogene Protein p21(ras)
NIH 3T3 Cells
DNA-Directed DNA Polymerase
DNA Repair
Vertebrates

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Transfected human β-polymerase promoter contains a ras-responsive element. / Kedar, P. S.; Lowy, D. R.; Widen, Steven; Wilson, S. H.

In: Molecular and Cellular Biology, Vol. 10, No. 7, 01.01.1990, p. 3852-3856.

Research output: Contribution to journalArticle

Kedar, P. S. ; Lowy, D. R. ; Widen, Steven ; Wilson, S. H. / Transfected human β-polymerase promoter contains a ras-responsive element. In: Molecular and Cellular Biology. 1990 ; Vol. 10, No. 7. pp. 3852-3856.
@article{b5bd62c0532c4093ab24a4915c933fd6,
title = "Transfected human β-polymerase promoter contains a ras-responsive element",
abstract = "β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21(v-ras(H)) expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.",
author = "Kedar, {P. S.} and Lowy, {D. R.} and Steven Widen and Wilson, {S. H.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1128/MCB.10.7.3852",
language = "English (US)",
volume = "10",
pages = "3852--3856",
journal = "Molecular and Cellular Biology",
issn = "0270-7306",
publisher = "American Society for Microbiology",
number = "7",

}

TY - JOUR

T1 - Transfected human β-polymerase promoter contains a ras-responsive element

AU - Kedar, P. S.

AU - Lowy, D. R.

AU - Widen, Steven

AU - Wilson, S. H.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21(v-ras(H)) expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.

AB - β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21(v-ras(H)) expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.

UR - http://www.scopus.com/inward/record.url?scp=0025365065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025365065&partnerID=8YFLogxK

U2 - 10.1128/MCB.10.7.3852

DO - 10.1128/MCB.10.7.3852

M3 - Article

C2 - 2192267

AN - SCOPUS:0025365065

VL - 10

SP - 3852

EP - 3856

JO - Molecular and Cellular Biology

JF - Molecular and Cellular Biology

SN - 0270-7306

IS - 7

ER -