Transfer Factor from BCG-Sensitized Mice

Kenji Sasaki, Fujio Suzuki, Nakao Ishida

Research output: Contribution to journalArticlepeer-review


A mouse model was established for the study of transfer factor (TF). TF was extracted from the spleens of sensitized mice and examined for activity by the footpad test, which showed that mouse and human TF possessed similar properties. Parenteral administration of TF imparted to unsensitized mice immunologically specific, delayed type hypersenstivity within 24 hr. The magnitude of the response the recipients showed was proportional to the dose of TF. TF activity was relatively heat-stable, detectable in a fraction of molecular weight of ca 1,000 and apparently contained nucleic acids. Nude mice responded negatively to TF but following administration of viable naive spleen cells a positive response was observed, which suggests that the thymus plays an important role in the expression of TF phenomenon and that the target of TF is the T cells.

Original languageEnglish (US)
Pages (from-to)271-283
Number of pages13
JournalThe Tohoku Journal of Experimental Medicine
Issue number3
StatePublished - 1980


  • BCG-sensitized mice
  • animal model
  • delayed type hypersensitivity
  • transfer factor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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