Transfer factor from BCG-sensitized mice

K. Sasaki, Fujio Suzuki, N. Ishida

Research output: Contribution to journalArticle

Abstract

A mouse model was established for the study of transfer factor (TF). TF was extracted from the spleens of sensitized mice and examined for activity by the footpad test, which showed that mouse and human TF possessed similar properties. Parental administration of TF imparted to unsensitized mice immunologically specific, delayed type hypersensitivity within 24 hr. The magnitude of the response the recipients showed was proportional to the dose of TF. TF activity was relatively heat-stable, detectable in a fraction of molecular weight of ca 1,000 and apparently contained nucleic acids. Nude mice responded negatively to TF but following administration of viable naive spleen cells a positive response was observed, which suggests that the thymus plays an important role in the expression of TF phenomenon and that the target of TF is the T cells.

Original languageEnglish (US)
Pages (from-to)271-283
Number of pages13
JournalTohoku Journal of Experimental Medicine
Volume131
Issue number3
StatePublished - 1980
Externally publishedYes

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Transfer Factor
Mycobacterium bovis
Spleen
Thymus
T-cells
Delayed Hypersensitivity
Nude Mice
Thymus Gland
Nucleic Acids
Hot Temperature
Molecular Weight
Molecular weight
T-Lymphocytes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Transfer factor from BCG-sensitized mice. / Sasaki, K.; Suzuki, Fujio; Ishida, N.

In: Tohoku Journal of Experimental Medicine, Vol. 131, No. 3, 1980, p. 271-283.

Research output: Contribution to journalArticle

Sasaki, K, Suzuki, F & Ishida, N 1980, 'Transfer factor from BCG-sensitized mice', Tohoku Journal of Experimental Medicine, vol. 131, no. 3, pp. 271-283.
Sasaki, K. ; Suzuki, Fujio ; Ishida, N. / Transfer factor from BCG-sensitized mice. In: Tohoku Journal of Experimental Medicine. 1980 ; Vol. 131, No. 3. pp. 271-283.
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