Transfer factor induced delayed hypersensitivity in X-linked combined immunodeficiency

Randall M. Goldblum; Ralph A. Lord; Elton Dupree; Arthur G. Weinberg; Armond S. Goldman

doi:10.1016/0008-8749(73)90081-6

Transfer factor induced delayed hypersensitivity in X-linked combined immunodeficiency

Randall M. Goldblum, Ralph A. Lord, Elton Dupree, Arthur G. Weinberg, Armond S. Goldman

Pediatrics

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A 5-month-old male with an X-linked combined immunodeficiency was treated with transfer factor. Consequently, lymphocyte stimulation to phytohemagglutinin and Candida as well as delayed hypersensitivity to candida and 2,4-dinitrochlorobenzene developed and persisted for 4 weeks. When cellular immunity diminished, the patient succumbed to Pneumocystis carinii and cytomegalovirus infections. Because of the transfer of cellular immunity in this case, further trials of transfer factor are indicated when histocompatible bone marrow is not available for patients with combined immunodeficiency.

Original language	English (US)
Pages (from-to)	297-305
Number of pages	9
Journal	Cellular Immunology
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(73)90081-6
State	Published - Nov 1973

ASJC Scopus subject areas

Immunology

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@article{000288659706491aabcf676d1fb7d42f,

title = "Transfer factor induced delayed hypersensitivity in X-linked combined immunodeficiency",

abstract = "A 5-month-old male with an X-linked combined immunodeficiency was treated with transfer factor. Consequently, lymphocyte stimulation to phytohemagglutinin and Candida as well as delayed hypersensitivity to candida and 2,4-dinitrochlorobenzene developed and persisted for 4 weeks. When cellular immunity diminished, the patient succumbed to Pneumocystis carinii and cytomegalovirus infections. Because of the transfer of cellular immunity in this case, further trials of transfer factor are indicated when histocompatible bone marrow is not available for patients with combined immunodeficiency.",

author = "Goldblum, {Randall M.} and Lord, {Ralph A.} and Elton Dupree and Weinberg, {Arthur G.} and Goldman, {Armond S.}",

note = "Funding Information: 1 Supported in part by NIH Grant No. DHEW 5 to 1 HD 00267 and NIH DHEW FR 00073, Division of Research Facilities and Resources.",

year = "1973",

month = nov,

doi = "10.1016/0008-8749(73)90081-6",

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T1 - Transfer factor induced delayed hypersensitivity in X-linked combined immunodeficiency

AU - Goldblum, Randall M.

AU - Lord, Ralph A.

AU - Dupree, Elton

AU - Weinberg, Arthur G.

AU - Goldman, Armond S.

N1 - Funding Information: 1 Supported in part by NIH Grant No. DHEW 5 to 1 HD 00267 and NIH DHEW FR 00073, Division of Research Facilities and Resources.

PY - 1973/11

Y1 - 1973/11

N2 - A 5-month-old male with an X-linked combined immunodeficiency was treated with transfer factor. Consequently, lymphocyte stimulation to phytohemagglutinin and Candida as well as delayed hypersensitivity to candida and 2,4-dinitrochlorobenzene developed and persisted for 4 weeks. When cellular immunity diminished, the patient succumbed to Pneumocystis carinii and cytomegalovirus infections. Because of the transfer of cellular immunity in this case, further trials of transfer factor are indicated when histocompatible bone marrow is not available for patients with combined immunodeficiency.

AB - A 5-month-old male with an X-linked combined immunodeficiency was treated with transfer factor. Consequently, lymphocyte stimulation to phytohemagglutinin and Candida as well as delayed hypersensitivity to candida and 2,4-dinitrochlorobenzene developed and persisted for 4 weeks. When cellular immunity diminished, the patient succumbed to Pneumocystis carinii and cytomegalovirus infections. Because of the transfer of cellular immunity in this case, further trials of transfer factor are indicated when histocompatible bone marrow is not available for patients with combined immunodeficiency.

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Transfer factor induced delayed hypersensitivity in X-linked combined immunodeficiency

Abstract

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