Transfer factor induced delayed hypersensitivity in X-linked combined immunodeficiency

Randall M. Goldblum, Ralph A. Lord, Elton Dupree, Arthur G. Weinberg, Armond S. Goldman

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A 5-month-old male with an X-linked combined immunodeficiency was treated with transfer factor. Consequently, lymphocyte stimulation to phytohemagglutinin and Candida as well as delayed hypersensitivity to candida and 2,4-dinitrochlorobenzene developed and persisted for 4 weeks. When cellular immunity diminished, the patient succumbed to Pneumocystis carinii and cytomegalovirus infections. Because of the transfer of cellular immunity in this case, further trials of transfer factor are indicated when histocompatible bone marrow is not available for patients with combined immunodeficiency.

Original languageEnglish (US)
Pages (from-to)297-305
Number of pages9
JournalCellular Immunology
Issue number2
StatePublished - Nov 1973

ASJC Scopus subject areas

  • Immunology


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