Transferrins, haptoglobins, and ceruloplasmins among tribal groups of Madagascar

John Buettner‐Janusch, Richard Reisman, Dorian Coppenhaver, George A. Mason, Vina Buettner‐Janusch

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Transferrin phenotypes of 403 Malagasy were determined by autoradiography after electrophoresis of plasma or serum. Three phenotypes, Tf C, Tf CD, and Tf D, were found. The frequency of TfD was 0.051 in the total sample, 0.041 in tribes of the Madagascar plateau, and 0.075 in tribes of the coastal and lowland regions. Haptoglobin phenotypes of 402 Malagasy were determined. The frequency of Hp1 was 0.41 in the total sample, 0.38 in tribes of the plateau, and 0.49 in coastal‐lowland tribes. There is a significant difference in the frequency of Hp1 between the tribes of the plateau and those of the coastal and lowland regions. This confirms earlier observations of significant differences in frequencies of haptoglobins and hemoglobin S. Plasma or serum samples from 405 Malagasy were examined by electrophoresis to determine ceruloplasmin phenotypes. Seven distinct ceruloplasmin bands were observed. These were A, B, Galveston, Bridgeport, New Haven, Tananarive, and X, the last two described for the first time. Ten different phenotypes composed of one or two of the bands were observed. The frequency of the allele for ceruloplasmin B (CpB) was 0.78 in the total sample, 0.73 in tribes of the plateau, and 0.92 in coastal and lowland tribes. There is a significant difference in the frequency of this allele in the two major tribal groups, and this provides additional evidence of genetic differences between the peoples of the plateau and those of the coast and lowland regions of Madagascar.

Original languageEnglish (US)
Pages (from-to)661-669
Number of pages9
JournalAmerican Journal of Physical Anthropology
Volume38
Issue number3
DOIs
StatePublished - May 1973

Keywords

  • Ceruloplasmin
  • Haptoglobin
  • Madagascar
  • Malagasy
  • Serum proteins
  • Transferrin

ASJC Scopus subject areas

  • Anatomy
  • Anthropology

Fingerprint Dive into the research topics of 'Transferrins, haptoglobins, and ceruloplasmins among tribal groups of Madagascar'. Together they form a unique fingerprint.

  • Cite this

    Buettner‐Janusch, J., Reisman, R., Coppenhaver, D., Mason, G. A., & Buettner‐Janusch, V. (1973). Transferrins, haptoglobins, and ceruloplasmins among tribal groups of Madagascar. American Journal of Physical Anthropology, 38(3), 661-669. https://doi.org/10.1002/ajpa.1330380303