Transformation of hamster embryonic fibroblast cells by UV-irradiated human cytomegalovirus.

Istvan Boldogh, E. Gönczöl, L. Váczi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Infection of hamster embryonic fibroblast (HEF) cells with UV-irradiated human CMV resulted in appearance of transformed clones. The established cell line (87-TRH-5) when inoculated subcutaneously induced tumour in newborn hamsters. The 87-TRH-5 cell line and the cell lines (87-TRH-5-Tsc1, 87-TRH-5-Tsc2, 87TRH-5-Tsc3) developed from the induced tumour, proved to bear CMV-spcific cytoplasmic and surface antigens. Demonstration of infectious CMV or MCV-specific nuclear antigen in 87-THR-5-cells has failed.

Original languageEnglish (US)
Pages (from-to)269-275
Number of pages7
JournalActa Microbiologica Academiae Scientiarum Hungaricae
Volume25
Issue number4
StatePublished - 1978
Externally publishedYes

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Cytomegalovirus
Cricetinae
Fibroblasts
Cell Line
Nuclear Antigens
Surface Antigens
Neoplasms
Clone Cells
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Transformation of hamster embryonic fibroblast cells by UV-irradiated human cytomegalovirus. / Boldogh, Istvan; Gönczöl, E.; Váczi, L.

In: Acta Microbiologica Academiae Scientiarum Hungaricae, Vol. 25, No. 4, 1978, p. 269-275.

Research output: Contribution to journalArticle

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