Transforming growth factor β1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in humans

P. Robinson; P. C. Okhuysen; C. L. Chappell; D. E. Lewis; I. Shahab; S. Lahoti; Jr White

doi:10.1128/IAI.68.9.5405-5407.2000

Transforming growth factor β1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in humans

P. Robinson, P. C. Okhuysen, C. L. Chappell, D. E. Lewis, I. Shahab, S. Lahoti, Jr White

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Biopsies from volunteers challenged with Cryptosporidium parvum were examined for transforming growth factor β1 (TGF-β1). None of the prechallenge biopsies exhibited TGF-β. Seven of 12 volunteers with oocyst shedding expressed TGF-β versus 2 of 13 volunteers without detected oocysts. The association of TGF-β expression with oocyst excretion and the timing of symptoms suggests that TGF-β mediates intestinal healing.

Original language	English (US)
Pages (from-to)	5405-5407
Number of pages	3
Journal	Infection and immunity
Volume	68
Issue number	9
DOIs	https://doi.org/10.1128/IAI.68.9.5405-5407.2000
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.68.9.5405-5407.2000

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title = "Transforming growth factor β1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in humans",

abstract = "Biopsies from volunteers challenged with Cryptosporidium parvum were examined for transforming growth factor β1 (TGF-β1). None of the prechallenge biopsies exhibited TGF-β. Seven of 12 volunteers with oocyst shedding expressed TGF-β versus 2 of 13 volunteers without detected oocysts. The association of TGF-β expression with oocyst excretion and the timing of symptoms suggests that TGF-β mediates intestinal healing.",

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AU - Robinson, P.

AU - Okhuysen, P. C.

AU - Chappell, C. L.

AU - Lewis, D. E.

AU - Shahab, I.

AU - Lahoti, S.

AU - White, Jr

PY - 2000

Y1 - 2000

N2 - Biopsies from volunteers challenged with Cryptosporidium parvum were examined for transforming growth factor β1 (TGF-β1). None of the prechallenge biopsies exhibited TGF-β. Seven of 12 volunteers with oocyst shedding expressed TGF-β versus 2 of 13 volunteers without detected oocysts. The association of TGF-β expression with oocyst excretion and the timing of symptoms suggests that TGF-β mediates intestinal healing.

AB - Biopsies from volunteers challenged with Cryptosporidium parvum were examined for transforming growth factor β1 (TGF-β1). None of the prechallenge biopsies exhibited TGF-β. Seven of 12 volunteers with oocyst shedding expressed TGF-β versus 2 of 13 volunteers without detected oocysts. The association of TGF-β expression with oocyst excretion and the timing of symptoms suggests that TGF-β mediates intestinal healing.

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Transforming growth factor β1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in humans

Abstract

ASJC Scopus subject areas

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