Transgenic and gene knock-out techniques and burn research

Steven Wolf, Kenneth J. Woodside

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The development of transgenic technology has given researchers a powerful tool to examine biological effects, and the response to injury is no exception. Techniques such as pronuclear injection, targeted homologous recombination, and Cre/loxP gene excision are being used to construct animals with specific genetic designs; these are exploited to learn the role of genes in the response to severe burn. We review the construction of transgenic animals, pitfalls and benefits of this relatively new technique, and how this technique has been used in burn research.

Original languageEnglish (US)
Pages (from-to)328-339
Number of pages12
JournalJournal of Surgical Research
Volume123
Issue number2
DOIs
StatePublished - Feb 1 2005
Externally publishedYes

Fingerprint

Gene Knockout Techniques
Genetically Modified Animals
Homologous Recombination
Research
Genes
Research Personnel
Technology
Injections
Wounds and Injuries

Keywords

  • burn
  • knock-out
  • transgenic

ASJC Scopus subject areas

  • Surgery

Cite this

Transgenic and gene knock-out techniques and burn research. / Wolf, Steven; Woodside, Kenneth J.

In: Journal of Surgical Research, Vol. 123, No. 2, 01.02.2005, p. 328-339.

Research output: Contribution to journalReview article

Wolf, Steven ; Woodside, Kenneth J. / Transgenic and gene knock-out techniques and burn research. In: Journal of Surgical Research. 2005 ; Vol. 123, No. 2. pp. 328-339.
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