Transgenic mice with SCA10 pentanucleotide repeats show motor phenotype and susceptibility to seizure: A toxic RNA gain-of-function model

Keyphrases

• Seizure 100%
• Transgenic Mice 100%
• Function Model 100%
• Spinocerebellar Ataxia Type 10 100%
• Toxic RNA 100%
• Motor Phenotype 100%
• RNA Gain-of-function 100%
• Pentanucleotide Repeat 100%
• 3′-untranslated Region (3′-UTR) 27%
• Neuronal Loss 18%
• Transgenic Mouse Model 18%
• Gain-of-function 18%
• Cellular Changes 18%
• Molecular Changes 18%
• RNA-based 18%
• HnRNP 18%
• Seizure Susceptibility 18%
• Apoptosis 9%
• Disease Mechanisms 9%
• Mitochondria 9%
• Clinical Phenotype 9%
• Protein Kinase 9%
• Sequestration 9%
• Hippocampus 9%
• Neurodegenerative Diseases 9%
• Autosomal Dominant 9%
• Gait 9%
• Ataxia 9%
• Sequester 9%
• Histopathological Changes 9%
• Gain-of-function mutation 9%
• Cerebral Cortex 9%
• Caspase-3 9%
• LacZ Gene 9%
• Prion 9%
• ATXN10 9%
• Neurological Phenotype 9%
• Cerebellar Ataxia 9%
• Pontine nuclei 9%
• SCA10 9%
• Gait Abnormalities 9%
• Mitochondrium 9%

Neuroscience

• Spinocerebellar Ataxia 100%
• Untranslated Region 27%
• Transgene 18%
• Ataxia 18%
• Heterogeneous Nuclear Ribonucleoprotein K 18%
• Mitochondrion 9%
• Promoter Region 9%
• Hippocampus 9%
• Caspase 3 9%
• Neurodegenerative Disorder 9%
• Intron 9%
• Cerebral Cortex 9%
• Prion Protein 9%
• Protein Kinase C 9%
• Pontine Nucleus 9%
• Gain of Function Mutation 9%
• Programmed Cell Death 9%