Transient electroencephalographic suppression with initiation of cardiopulmonary bypass in pigs

Blood versus nonblood priming

Brendan P. Conroy, Cheng Y. Lin, Larry W. Jenkins, Douglas Dewitt, William E. Johnston

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Electroencephalographic (EEG) changes have been reported with cardiopulmonary bypass (CPB). We tested whether the type of priming solution (blood versus nonblood) affected the EEG. Twenty-six anesthetized pigs (29.5 ± 1.6 kg) were cannulated for CPB primed with 1 liter plasmalyte and 500 ml 6% hetastarch (nonblood prime). EEG signals were recorded during the initiation of normothermic CPB. Three minutes later, animals were weaned from CPB and allowed to stabilize. CPB was reinstituted using the animals' hemodiluted blood as prime. We found that with nonblood prime, abrupt and marked EEG suppression lasting 12.6 ± 0.7 s was found in all animals, followed by gradual resumption of baseline EEG activity. In contrast, CPB with blood prime caused no detectable EEG changes. We conclude that severe reductions in EEG activity occur after initiating CPB with nonblood prime; these reductions are not seen when using blood prime. The cause of EEG suppression is unknown, but may represent transient impairment of oxygen delivery to the brain caused by nonblood perfusion.

Original languageEnglish (US)
Pages (from-to)337-340
Number of pages4
JournalPerfusion
Volume14
Issue number5
StatePublished - 1999

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suppression
Cardiopulmonary Bypass
Blood
Swine
animal
Animals
brain
Brain
Hydroxyethyl Starch Derivatives
cause
Oxygen
Perfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Transient electroencephalographic suppression with initiation of cardiopulmonary bypass in pigs : Blood versus nonblood priming. / Conroy, Brendan P.; Lin, Cheng Y.; Jenkins, Larry W.; Dewitt, Douglas; Johnston, William E.

In: Perfusion, Vol. 14, No. 5, 1999, p. 337-340.

Research output: Contribution to journalArticle

Conroy, Brendan P. ; Lin, Cheng Y. ; Jenkins, Larry W. ; Dewitt, Douglas ; Johnston, William E. / Transient electroencephalographic suppression with initiation of cardiopulmonary bypass in pigs : Blood versus nonblood priming. In: Perfusion. 1999 ; Vol. 14, No. 5. pp. 337-340.
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