Transient hyperglycemia in hispanic children with acute lymphoblastic leukemia

Jacques Baillargeon, Anne Marie Langevin, Judith Mullins, Robert J. Ferry, Guillermo DeAngulo, Paul J. Thomas, Jaime Estrada, Aaron Pitney, Brad H. Pollock

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background. Transient hyperglycemia occurs commonly during the treatment for childhood acute lymphoblastic leukemia (ALL). The purpose of this study was to examine the incidence of and risk factors for transient hyperglycemia during induction chemotherapy in Hispanic pediatric patients diagnosed with B-Precursor ALL. Procedure. The study cohort consisted of 155 Hispanic pediatric patients diagnosed with ALL and treated at one of two South Texas pediatric oncology centers between 1993 and 2002. Hyperglycemia was defined as ≥2 glucose determinations of ≥200 mg/dl during the first 28 days of induction chemotherapy. Results. Overall, 11.0% of the study cohort developed transient hyperglycemia during induction chemotherapy. Age and body mass index (BMI) were both positively associated with the risk of hyperglycemia. Females exhibited a substantially higher risk of hyperglycemia than males, but this association did not reach statistical significance after adjusting for other covariates. Among patients who developed hyperglycemia, 100% of those who required insulin were in the 13-18-year age group and reported a family history of diabetes. Hyperglycemic patients classified as obese (BMI ≥95 centile) were more than twice as likely to have required insulin therapy compared to overweight patients (BMI 85-<95 centile) and three times as likely to have required insulin compared to normal weight (BMI <85 centile) patients. Conclusions. The incidence of chemotherapy-induced transient hyperglycemia in the present study cohort is comparable to that reported in previous pediatric ALL patients. This finding is interesting in view of the elevated prevalence of obesity and the underlying dietary behaviors in this Hispanic study cohort.

Original languageEnglish (US)
Pages (from-to)960-963
Number of pages4
JournalPediatric Blood and Cancer
Volume45
Issue number7
DOIs
StatePublished - Dec 2005
Externally publishedYes

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hispanic Americans
Hyperglycemia
Induction Chemotherapy
Body Mass Index
Cohort Studies
Pediatrics
Insulin
Incidence
Age Groups
Obesity
Weights and Measures
Glucose
Drug Therapy
Therapeutics

Keywords

  • Acute lymphoblastic leukemia
  • Children
  • Glucose
  • Obesity

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Baillargeon, J., Langevin, A. M., Mullins, J., Ferry, R. J., DeAngulo, G., Thomas, P. J., ... Pollock, B. H. (2005). Transient hyperglycemia in hispanic children with acute lymphoblastic leukemia. Pediatric Blood and Cancer, 45(7), 960-963. https://doi.org/10.1002/pbc.20320

Transient hyperglycemia in hispanic children with acute lymphoblastic leukemia. / Baillargeon, Jacques; Langevin, Anne Marie; Mullins, Judith; Ferry, Robert J.; DeAngulo, Guillermo; Thomas, Paul J.; Estrada, Jaime; Pitney, Aaron; Pollock, Brad H.

In: Pediatric Blood and Cancer, Vol. 45, No. 7, 12.2005, p. 960-963.

Research output: Contribution to journalArticle

Baillargeon, J, Langevin, AM, Mullins, J, Ferry, RJ, DeAngulo, G, Thomas, PJ, Estrada, J, Pitney, A & Pollock, BH 2005, 'Transient hyperglycemia in hispanic children with acute lymphoblastic leukemia', Pediatric Blood and Cancer, vol. 45, no. 7, pp. 960-963. https://doi.org/10.1002/pbc.20320
Baillargeon, Jacques ; Langevin, Anne Marie ; Mullins, Judith ; Ferry, Robert J. ; DeAngulo, Guillermo ; Thomas, Paul J. ; Estrada, Jaime ; Pitney, Aaron ; Pollock, Brad H. / Transient hyperglycemia in hispanic children with acute lymphoblastic leukemia. In: Pediatric Blood and Cancer. 2005 ; Vol. 45, No. 7. pp. 960-963.
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abstract = "Background. Transient hyperglycemia occurs commonly during the treatment for childhood acute lymphoblastic leukemia (ALL). The purpose of this study was to examine the incidence of and risk factors for transient hyperglycemia during induction chemotherapy in Hispanic pediatric patients diagnosed with B-Precursor ALL. Procedure. The study cohort consisted of 155 Hispanic pediatric patients diagnosed with ALL and treated at one of two South Texas pediatric oncology centers between 1993 and 2002. Hyperglycemia was defined as ≥2 glucose determinations of ≥200 mg/dl during the first 28 days of induction chemotherapy. Results. Overall, 11.0{\%} of the study cohort developed transient hyperglycemia during induction chemotherapy. Age and body mass index (BMI) were both positively associated with the risk of hyperglycemia. Females exhibited a substantially higher risk of hyperglycemia than males, but this association did not reach statistical significance after adjusting for other covariates. Among patients who developed hyperglycemia, 100{\%} of those who required insulin were in the 13-18-year age group and reported a family history of diabetes. Hyperglycemic patients classified as obese (BMI ≥95 centile) were more than twice as likely to have required insulin therapy compared to overweight patients (BMI 85-<95 centile) and three times as likely to have required insulin compared to normal weight (BMI <85 centile) patients. Conclusions. The incidence of chemotherapy-induced transient hyperglycemia in the present study cohort is comparable to that reported in previous pediatric ALL patients. This finding is interesting in view of the elevated prevalence of obesity and the underlying dietary behaviors in this Hispanic study cohort.",
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AU - Langevin, Anne Marie

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AU - Thomas, Paul J.

AU - Estrada, Jaime

AU - Pitney, Aaron

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N2 - Background. Transient hyperglycemia occurs commonly during the treatment for childhood acute lymphoblastic leukemia (ALL). The purpose of this study was to examine the incidence of and risk factors for transient hyperglycemia during induction chemotherapy in Hispanic pediatric patients diagnosed with B-Precursor ALL. Procedure. The study cohort consisted of 155 Hispanic pediatric patients diagnosed with ALL and treated at one of two South Texas pediatric oncology centers between 1993 and 2002. Hyperglycemia was defined as ≥2 glucose determinations of ≥200 mg/dl during the first 28 days of induction chemotherapy. Results. Overall, 11.0% of the study cohort developed transient hyperglycemia during induction chemotherapy. Age and body mass index (BMI) were both positively associated with the risk of hyperglycemia. Females exhibited a substantially higher risk of hyperglycemia than males, but this association did not reach statistical significance after adjusting for other covariates. Among patients who developed hyperglycemia, 100% of those who required insulin were in the 13-18-year age group and reported a family history of diabetes. Hyperglycemic patients classified as obese (BMI ≥95 centile) were more than twice as likely to have required insulin therapy compared to overweight patients (BMI 85-<95 centile) and three times as likely to have required insulin compared to normal weight (BMI <85 centile) patients. Conclusions. The incidence of chemotherapy-induced transient hyperglycemia in the present study cohort is comparable to that reported in previous pediatric ALL patients. This finding is interesting in view of the elevated prevalence of obesity and the underlying dietary behaviors in this Hispanic study cohort.

AB - Background. Transient hyperglycemia occurs commonly during the treatment for childhood acute lymphoblastic leukemia (ALL). The purpose of this study was to examine the incidence of and risk factors for transient hyperglycemia during induction chemotherapy in Hispanic pediatric patients diagnosed with B-Precursor ALL. Procedure. The study cohort consisted of 155 Hispanic pediatric patients diagnosed with ALL and treated at one of two South Texas pediatric oncology centers between 1993 and 2002. Hyperglycemia was defined as ≥2 glucose determinations of ≥200 mg/dl during the first 28 days of induction chemotherapy. Results. Overall, 11.0% of the study cohort developed transient hyperglycemia during induction chemotherapy. Age and body mass index (BMI) were both positively associated with the risk of hyperglycemia. Females exhibited a substantially higher risk of hyperglycemia than males, but this association did not reach statistical significance after adjusting for other covariates. Among patients who developed hyperglycemia, 100% of those who required insulin were in the 13-18-year age group and reported a family history of diabetes. Hyperglycemic patients classified as obese (BMI ≥95 centile) were more than twice as likely to have required insulin therapy compared to overweight patients (BMI 85-<95 centile) and three times as likely to have required insulin compared to normal weight (BMI <85 centile) patients. Conclusions. The incidence of chemotherapy-induced transient hyperglycemia in the present study cohort is comparable to that reported in previous pediatric ALL patients. This finding is interesting in view of the elevated prevalence of obesity and the underlying dietary behaviors in this Hispanic study cohort.

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