Transient ischemia cannot precondition the rabbit heart against postischemic contractile dysfunction

Gregory K. Asimakis, Scott D. Lick, Vincent Conti

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background. The rat heart is preconditioned against postischemic contractile dysfunction by a brief period of transient ischemia before a prolonged ischemic period. However, the rabbit heart does not receive such cardioprotection from pretreatment with a single transient ischemia periods. We hypothesized that in the rabbit heart, a multiple cycle of transient ischemia is required to reach a threshold necessary to precondition against postischemic contractile dysfunction. Methods. To test this hypothesis, we subjected isolated, perfused rabbit hearts to either one 5-minute transient ischemic period or three 5-minute transient ischemic periods followed by a 40-minute period of warm ischemia and 30 minutes of reperfusion. Control hearts (no pretreatment with transient ischemia) were examined simultaneously. Left ventricular developed pressure was measured with an intraventricular balloon. Results. Postischemic recoveries (expressed as percent of preischemic values) of left ventricular developed pressure for the group with one ischemic period and the group with three ischemic periods were 43% ± 5% (n = 5) and 38% ± 6% (n = 6), respectively. These values were not significantly different from control values. Conclusions. Neither one nor three periods of transient ischemia protect the isolated, perfused rabbit heart from postischemic contractile dysfunction. Therefore, the rabbit heart may not have the capacity to be ischemically preconditioned against postischemic contractile dysfunction.

Original languageEnglish
Pages (from-to)543-549
Number of pages7
JournalAnnals of Thoracic Surgery
Volume62
Issue number2
DOIs
StatePublished - Aug 1996

Fingerprint

Ischemia
Rabbits
Ventricular Pressure
Warm Ischemia
Reperfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Transient ischemia cannot precondition the rabbit heart against postischemic contractile dysfunction. / Asimakis, Gregory K.; Lick, Scott D.; Conti, Vincent.

In: Annals of Thoracic Surgery, Vol. 62, No. 2, 08.1996, p. 543-549.

Research output: Contribution to journalArticle

@article{20538d875c784f11b875a80c501f4704,
title = "Transient ischemia cannot precondition the rabbit heart against postischemic contractile dysfunction",
abstract = "Background. The rat heart is preconditioned against postischemic contractile dysfunction by a brief period of transient ischemia before a prolonged ischemic period. However, the rabbit heart does not receive such cardioprotection from pretreatment with a single transient ischemia periods. We hypothesized that in the rabbit heart, a multiple cycle of transient ischemia is required to reach a threshold necessary to precondition against postischemic contractile dysfunction. Methods. To test this hypothesis, we subjected isolated, perfused rabbit hearts to either one 5-minute transient ischemic period or three 5-minute transient ischemic periods followed by a 40-minute period of warm ischemia and 30 minutes of reperfusion. Control hearts (no pretreatment with transient ischemia) were examined simultaneously. Left ventricular developed pressure was measured with an intraventricular balloon. Results. Postischemic recoveries (expressed as percent of preischemic values) of left ventricular developed pressure for the group with one ischemic period and the group with three ischemic periods were 43{\%} ± 5{\%} (n = 5) and 38{\%} ± 6{\%} (n = 6), respectively. These values were not significantly different from control values. Conclusions. Neither one nor three periods of transient ischemia protect the isolated, perfused rabbit heart from postischemic contractile dysfunction. Therefore, the rabbit heart may not have the capacity to be ischemically preconditioned against postischemic contractile dysfunction.",
author = "Asimakis, {Gregory K.} and Lick, {Scott D.} and Vincent Conti",
year = "1996",
month = "8",
doi = "10.1016/0003-4975(96)00423-7",
language = "English",
volume = "62",
pages = "543--549",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "Elsevier USA",
number = "2",

}

TY - JOUR

T1 - Transient ischemia cannot precondition the rabbit heart against postischemic contractile dysfunction

AU - Asimakis, Gregory K.

AU - Lick, Scott D.

AU - Conti, Vincent

PY - 1996/8

Y1 - 1996/8

N2 - Background. The rat heart is preconditioned against postischemic contractile dysfunction by a brief period of transient ischemia before a prolonged ischemic period. However, the rabbit heart does not receive such cardioprotection from pretreatment with a single transient ischemia periods. We hypothesized that in the rabbit heart, a multiple cycle of transient ischemia is required to reach a threshold necessary to precondition against postischemic contractile dysfunction. Methods. To test this hypothesis, we subjected isolated, perfused rabbit hearts to either one 5-minute transient ischemic period or three 5-minute transient ischemic periods followed by a 40-minute period of warm ischemia and 30 minutes of reperfusion. Control hearts (no pretreatment with transient ischemia) were examined simultaneously. Left ventricular developed pressure was measured with an intraventricular balloon. Results. Postischemic recoveries (expressed as percent of preischemic values) of left ventricular developed pressure for the group with one ischemic period and the group with three ischemic periods were 43% ± 5% (n = 5) and 38% ± 6% (n = 6), respectively. These values were not significantly different from control values. Conclusions. Neither one nor three periods of transient ischemia protect the isolated, perfused rabbit heart from postischemic contractile dysfunction. Therefore, the rabbit heart may not have the capacity to be ischemically preconditioned against postischemic contractile dysfunction.

AB - Background. The rat heart is preconditioned against postischemic contractile dysfunction by a brief period of transient ischemia before a prolonged ischemic period. However, the rabbit heart does not receive such cardioprotection from pretreatment with a single transient ischemia periods. We hypothesized that in the rabbit heart, a multiple cycle of transient ischemia is required to reach a threshold necessary to precondition against postischemic contractile dysfunction. Methods. To test this hypothesis, we subjected isolated, perfused rabbit hearts to either one 5-minute transient ischemic period or three 5-minute transient ischemic periods followed by a 40-minute period of warm ischemia and 30 minutes of reperfusion. Control hearts (no pretreatment with transient ischemia) were examined simultaneously. Left ventricular developed pressure was measured with an intraventricular balloon. Results. Postischemic recoveries (expressed as percent of preischemic values) of left ventricular developed pressure for the group with one ischemic period and the group with three ischemic periods were 43% ± 5% (n = 5) and 38% ± 6% (n = 6), respectively. These values were not significantly different from control values. Conclusions. Neither one nor three periods of transient ischemia protect the isolated, perfused rabbit heart from postischemic contractile dysfunction. Therefore, the rabbit heart may not have the capacity to be ischemically preconditioned against postischemic contractile dysfunction.

UR - http://www.scopus.com/inward/record.url?scp=0030219176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030219176&partnerID=8YFLogxK

U2 - 10.1016/0003-4975(96)00423-7

DO - 10.1016/0003-4975(96)00423-7

M3 - Article

C2 - 8694620

AN - SCOPUS:0030219176

VL - 62

SP - 543

EP - 549

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 2

ER -