Abstract
Numerous studies have demonstrated the importance of the adaptive immunity for survival following Ebola virus (EBOV) infection. To evaluate the contribution of tissue damage to EBOV-induced immune suppression, acute liver damage or hemolysis, 2 symptoms associated with lethal EBOV infection, were chemically induced in vaccinated mice. Results show that either liver damage or hemolysis was sufficient to inhibit the host humoral response against EBOV glycoprotein and to drastically reduce the level of circulating T cells. This study thus provides a possible mechanism for the limited specific antibody production and lymphopenia in individuals with lethal hemorrhagic fever infections.
Original language | English (US) |
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Pages (from-to) | 1852-1855 |
Number of pages | 4 |
Journal | Journal of Infectious Diseases |
Volume | 225 |
Issue number | 10 |
DOIs | |
State | Published - May 15 2022 |
Externally published | Yes |
Keywords
- Ebola virus
- humoral response
- lymphopenia
- tissue damage
ASJC Scopus subject areas
- General Medicine