Translocation (5; 11) in a conjunctival MALT lymphoma

Cecilia Clement, Venkateswara R. Potluri, John Gonzales, You-Wen Qian

Research output: Contribution to journalArticle

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Abstract

Lymphoma is the most frequent malignant tumor of the ocular adnexa with the most common histologic type being extranodal marginal zone B-cell lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT lymphoma). Here we report a case of a 28 year-old male who presented with a left conjunctival mass of one year duration. A diagnosis of primary MALT lymphoma of the conjunctiva was made based on morphologic and immunophenotypic studies. Chromosome analysis revealed a male karyotype with a translocation t (5;11) (q33;p11.2) as the primary chromosomal abnormality, which, to the best of our knowledge, is the first reported translocation in MALT lymphomas and ocular MALT lymphomas as well.

Original languageEnglish (US)
Pages (from-to)722-726
Number of pages5
JournalInternational Journal of Clinical and Experimental Pathology
Volume4
Issue number7
StatePublished - 2011

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Keywords

  • Conjunctiva
  • MALT lymphoma
  • Ocular
  • Translocation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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