Transmembrane scf nanodiscs enhance revascularization in ischemia and induce cd34-/cd133+ endothelial progenitor cells

Eri Takematsu, Jeff Auster, Aditya Singh, Po Chih Chen, Sophia Canga, Andre Degroot, Michael Sherman, Jeanne Stachowiak, Andrew K. Dunn, Aaron B. Baker

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Diabetes mellitus affects approximately 350 million people, leading to the death of about 4.6 million people in the world. 20-30% of patients with diabetes develop peripheral vascular disease (PVD), among which 25% require amputation, causing a decrease in quality of life. Standard cares of PVD such as stenting are often invasive, so demand for noninvasive treatment is rising. Method that may fulfill such needs is a protein therapy that revives the blood flow in ischemic area. Previously, we explored the use of transmembrane stem cell factor (tmSCF) as a therapeutic protein for restoring blood flow at ischemic area. We found a significant higher blood flow recovery after hind limb ischemia surgery when treated with tmSCF proteoliposomes (PLs) and nanodiscs (NDs). In this research, we hypothesize that tmSCFPLs/NDs stimulate bone marrow cells (BMCs) and increase the CD34-CD133+ subpopulation of endothelial progenitor cells (EPCs). Moreover, enhanced mobilization of EPCs to peripheral blood (PB) was confirmed when treated with tmSCFNDs.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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    Takematsu, E., Auster, J., Singh, A., Chen, P. C., Canga, S., Degroot, A., Sherman, M., Stachowiak, J., Dunn, A. K., & Baker, A. B. (2019). Transmembrane scf nanodiscs enhance revascularization in ischemia and induce cd34-/cd133+ endothelial progenitor cells. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.