Abstract
We proposed to use transmission (forward) mode for cerebral, noninvasive, transcranial optoacoustic monitoring, imaging, and sensing in humans. In the transmission mode, the irradiation of the tissue of interest and detection of optoacoustic signals are performed from opposite hemispheres, while in the reflection (backward) mode the irradiation of the tissue of interest and detection of optoacoustic signals are performed from the same hemisphere. Recently, we developed new, transmission-mode optoacoustic probes for patients with traumatic brain injury (TBI) and for neonatal patients. The transmission mode probes have two major parts: a fiber-optic delivery system and an acoustic transducer (sensor). To obtain optoacoustic signals in the transmission mode, in this study we placed the sensor on the forehead, while light was delivered to the opposite side of the head. Using a medical grade, multi-wavelength, OPObased optoacoustic system tunable in the near infrared spectral range (680-950 nm) and a novel, compact, fiber-coupled, multi-wavelength, pulsed laser diode-based system, we recorded optoacoustic signals generated in the posterior part of the head of adults with TBI and neonates. The optoacoustic signals had two distinct peaks: the first peak from the intracranial space and the second peak from the scalp. The first peak generated by cerebral blood was used to measure cerebral blood oxygenation. Moreover, the transmission mode measurements provided detection of intracranial hematomas in the TBI patients. The obtained results suggest that the transmission mode can be used for optoacoustic brain imaging, tomography, and mapping in humans.
Original language | English (US) |
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Title of host publication | Photons Plus Ultrasound: Imaging and Sensing 2016 |
Publisher | SPIE |
Volume | 9708 |
ISBN (Electronic) | 9781628419429 |
DOIs | |
State | Published - 2016 |
Event | Photons Plus Ultrasound: Imaging and Sensing 2016 - San Francisco, United States Duration: Feb 14 2016 → Feb 17 2016 |
Other
Other | Photons Plus Ultrasound: Imaging and Sensing 2016 |
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Country | United States |
City | San Francisco |
Period | 2/14/16 → 2/17/16 |
Keywords
- cerebral ischemia
- cerebral oxygenation
- imaging
- noninvasive monitoring
- Optoacoustic
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging