TY - GEN
T1 - Transmission (forward) mode, transcranial, noninvasive optoacoustic measurements for brain monitoring, imaging, and sensing
AU - Petrov, Irene Y.
AU - Petrov, Yuriy
AU - Prough, Donald S.
AU - Richardson, C. Joan
AU - Fonseca, Rafael A.
AU - Robertson, Claudia S.
AU - Asokan, C. Vasantha
AU - Agbor, Adaeze
AU - Esenaliev, Rinat O.
N1 - Funding Information:
This work is supported in part by the National Institutes of Health (Research Grants #R41HD076568 and #R43HD075551 form the Eunice Kennedy Shriver National Institute of Child Health & Human Development, #R41HL10309501 from the National Heart, Lung and Blood Institute, #U54EB007954 from the National Institute of Biomedical Imaging and Bioengineering, and #R41HL10309501 from the National Heart, Lung and Blood Institute), contracts from Noninvasix, Inc., the Texas Emerging Technology Fund, and the Moody Center for Brain and Spinal Cord Injury Research/Mission Connect of UTMB.
Publisher Copyright:
© 2016 SPIE.
PY - 2016
Y1 - 2016
N2 - We proposed to use transmission (forward) mode for cerebral, noninvasive, transcranial optoacoustic monitoring, imaging, and sensing in humans. In the transmission mode, the irradiation of the tissue of interest and detection of optoacoustic signals are performed from opposite hemispheres, while in the reflection (backward) mode the irradiation of the tissue of interest and detection of optoacoustic signals are performed from the same hemisphere. Recently, we developed new, transmission-mode optoacoustic probes for patients with traumatic brain injury (TBI) and for neonatal patients. The transmission mode probes have two major parts: a fiber-optic delivery system and an acoustic transducer (sensor). To obtain optoacoustic signals in the transmission mode, in this study we placed the sensor on the forehead, while light was delivered to the opposite side of the head. Using a medical grade, multi-wavelength, OPObased optoacoustic system tunable in the near infrared spectral range (680-950 nm) and a novel, compact, fiber-coupled, multi-wavelength, pulsed laser diode-based system, we recorded optoacoustic signals generated in the posterior part of the head of adults with TBI and neonates. The optoacoustic signals had two distinct peaks: the first peak from the intracranial space and the second peak from the scalp. The first peak generated by cerebral blood was used to measure cerebral blood oxygenation. Moreover, the transmission mode measurements provided detection of intracranial hematomas in the TBI patients. The obtained results suggest that the transmission mode can be used for optoacoustic brain imaging, tomography, and mapping in humans.
AB - We proposed to use transmission (forward) mode for cerebral, noninvasive, transcranial optoacoustic monitoring, imaging, and sensing in humans. In the transmission mode, the irradiation of the tissue of interest and detection of optoacoustic signals are performed from opposite hemispheres, while in the reflection (backward) mode the irradiation of the tissue of interest and detection of optoacoustic signals are performed from the same hemisphere. Recently, we developed new, transmission-mode optoacoustic probes for patients with traumatic brain injury (TBI) and for neonatal patients. The transmission mode probes have two major parts: a fiber-optic delivery system and an acoustic transducer (sensor). To obtain optoacoustic signals in the transmission mode, in this study we placed the sensor on the forehead, while light was delivered to the opposite side of the head. Using a medical grade, multi-wavelength, OPObased optoacoustic system tunable in the near infrared spectral range (680-950 nm) and a novel, compact, fiber-coupled, multi-wavelength, pulsed laser diode-based system, we recorded optoacoustic signals generated in the posterior part of the head of adults with TBI and neonates. The optoacoustic signals had two distinct peaks: the first peak from the intracranial space and the second peak from the scalp. The first peak generated by cerebral blood was used to measure cerebral blood oxygenation. Moreover, the transmission mode measurements provided detection of intracranial hematomas in the TBI patients. The obtained results suggest that the transmission mode can be used for optoacoustic brain imaging, tomography, and mapping in humans.
KW - Optoacoustic
KW - cerebral ischemia
KW - cerebral oxygenation
KW - imaging
KW - noninvasive monitoring
UR - http://www.scopus.com/inward/record.url?scp=84975041798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975041798&partnerID=8YFLogxK
U2 - 10.1117/12.2218919
DO - 10.1117/12.2218919
M3 - Conference contribution
AN - SCOPUS:84975041798
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photons Plus Ultrasound
A2 - Oraevsky, Alexander A.
A2 - Wang, Lihong V.
PB - SPIE
T2 - Photons Plus Ultrasound: Imaging and Sensing 2016
Y2 - 14 February 2016 through 17 February 2016
ER -