Transmission (forward) mode, transcranial, noninvasive optoacoustic measurements for brain monitoring, imaging, and sensing

Irene Y. Petrov, Yuriy Petrov, Donald Prough, Carol Richardson, Rafael Fonseca, Claudia S. Robertson, C. Vasantha Asokan, Adaeze Agbor, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

We proposed to use transmission (forward) mode for cerebral, noninvasive, transcranial optoacoustic monitoring, imaging, and sensing in humans. In the transmission mode, the irradiation of the tissue of interest and detection of optoacoustic signals are performed from opposite hemispheres, while in the reflection (backward) mode the irradiation of the tissue of interest and detection of optoacoustic signals are performed from the same hemisphere. Recently, we developed new, transmission-mode optoacoustic probes for patients with traumatic brain injury (TBI) and for neonatal patients. The transmission mode probes have two major parts: a fiber-optic delivery system and an acoustic transducer (sensor). To obtain optoacoustic signals in the transmission mode, in this study we placed the sensor on the forehead, while light was delivered to the opposite side of the head. Using a medical grade, multi-wavelength, OPObased optoacoustic system tunable in the near infrared spectral range (680-950 nm) and a novel, compact, fiber-coupled, multi-wavelength, pulsed laser diode-based system, we recorded optoacoustic signals generated in the posterior part of the head of adults with TBI and neonates. The optoacoustic signals had two distinct peaks: the first peak from the intracranial space and the second peak from the scalp. The first peak generated by cerebral blood was used to measure cerebral blood oxygenation. Moreover, the transmission mode measurements provided detection of intracranial hematomas in the TBI patients. The obtained results suggest that the transmission mode can be used for optoacoustic brain imaging, tomography, and mapping in humans.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound: Imaging and Sensing 2016
PublisherSPIE
Volume9708
ISBN (Electronic)9781628419429
DOIs
StatePublished - 2016
EventPhotons Plus Ultrasound: Imaging and Sensing 2016 - San Francisco, United States
Duration: Feb 14 2016Feb 17 2016

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2016
CountryUnited States
CitySan Francisco
Period2/14/162/17/16

Fingerprint

Photoacoustic effect
Neuroimaging
brain
Brain
Imaging techniques
Monitoring
brain damage
Head
Brain Mapping
Forehead
Scalp
Transducers
Acoustics
Hematoma
Lasers
hemispheres
Tomography
Newborn Infant
blood
Light

Keywords

  • cerebral ischemia
  • cerebral oxygenation
  • imaging
  • noninvasive monitoring
  • Optoacoustic

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Transmission (forward) mode, transcranial, noninvasive optoacoustic measurements for brain monitoring, imaging, and sensing. / Petrov, Irene Y.; Petrov, Yuriy; Prough, Donald; Richardson, Carol; Fonseca, Rafael; Robertson, Claudia S.; Asokan, C. Vasantha; Agbor, Adaeze; Esenaliev, Rinat.

Photons Plus Ultrasound: Imaging and Sensing 2016. Vol. 9708 SPIE, 2016. 97084P.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Petrov, IY, Petrov, Y, Prough, D, Richardson, C, Fonseca, R, Robertson, CS, Asokan, CV, Agbor, A & Esenaliev, R 2016, Transmission (forward) mode, transcranial, noninvasive optoacoustic measurements for brain monitoring, imaging, and sensing. in Photons Plus Ultrasound: Imaging and Sensing 2016. vol. 9708, 97084P, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2016, San Francisco, United States, 2/14/16. https://doi.org/10.1117/12.2218919
Petrov, Irene Y. ; Petrov, Yuriy ; Prough, Donald ; Richardson, Carol ; Fonseca, Rafael ; Robertson, Claudia S. ; Asokan, C. Vasantha ; Agbor, Adaeze ; Esenaliev, Rinat. / Transmission (forward) mode, transcranial, noninvasive optoacoustic measurements for brain monitoring, imaging, and sensing. Photons Plus Ultrasound: Imaging and Sensing 2016. Vol. 9708 SPIE, 2016.
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