Abstract
We proposed to use transmission (forward) mode for cerebral, noninvasive, transcranial optoacoustic monitoring, imaging, and sensing in humans. In the transmission mode, the irradiation of the tissue of interest and detection of optoacoustic signals are performed from opposite hemispheres, while in the reflection (backward) mode the irradiation of the tissue of interest and detection of optoacoustic signals are performed from the same hemisphere. Recently, we developed new, transmission-mode optoacoustic probes for patients with traumatic brain injury (TBI) and for neonatal patients. The transmission mode probes have two major parts: a fiber-optic delivery system and an acoustic transducer (sensor). To obtain optoacoustic signals in the transmission mode, in this study we placed the sensor on the forehead, while light was delivered to the opposite side of the head. Using a medical grade, multi-wavelength, OPObased optoacoustic system tunable in the near infrared spectral range (680-950 nm) and a novel, compact, fiber-coupled, multi-wavelength, pulsed laser diode-based system, we recorded optoacoustic signals generated in the posterior part of the head of adults with TBI and neonates. The optoacoustic signals had two distinct peaks: the first peak from the intracranial space and the second peak from the scalp. The first peak generated by cerebral blood was used to measure cerebral blood oxygenation. Moreover, the transmission mode measurements provided detection of intracranial hematomas in the TBI patients. The obtained results suggest that the transmission mode can be used for optoacoustic brain imaging, tomography, and mapping in humans.
| Original language | English (US) |
|---|---|
| Title of host publication | Photons Plus Ultrasound: Imaging and Sensing 2016 |
| Publisher | SPIE |
| Volume | 9708 |
| ISBN (Electronic) | 9781628419429 |
| DOIs | |
| State | Published - 2016 |
| Event | Photons Plus Ultrasound: Imaging and Sensing 2016 - San Francisco, United States Duration: Feb 14 2016 → Feb 17 2016 |
Other
| Other | Photons Plus Ultrasound: Imaging and Sensing 2016 |
|---|---|
| Country | United States |
| City | San Francisco |
| Period | 2/14/16 → 2/17/16 |
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Keywords
- cerebral ischemia
- cerebral oxygenation
- imaging
- noninvasive monitoring
- Optoacoustic
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
Transmission (forward) mode, transcranial, noninvasive optoacoustic measurements for brain monitoring, imaging, and sensing. / Petrov, Irene Y.; Petrov, Yuriy; Prough, Donald; Richardson, Carol; Fonseca, Rafael; Robertson, Claudia S.; Asokan, C. Vasantha; Agbor, Adaeze; Esenaliev, Rinat.
Photons Plus Ultrasound: Imaging and Sensing 2016. Vol. 9708 SPIE, 2016. 97084P.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Transmission (forward) mode, transcranial, noninvasive optoacoustic measurements for brain monitoring, imaging, and sensing
AU - Petrov, Irene Y.
AU - Petrov, Yuriy
AU - Prough, Donald
AU - Richardson, Carol
AU - Fonseca, Rafael
AU - Robertson, Claudia S.
AU - Asokan, C. Vasantha
AU - Agbor, Adaeze
AU - Esenaliev, Rinat
PY - 2016
Y1 - 2016
N2 - We proposed to use transmission (forward) mode for cerebral, noninvasive, transcranial optoacoustic monitoring, imaging, and sensing in humans. In the transmission mode, the irradiation of the tissue of interest and detection of optoacoustic signals are performed from opposite hemispheres, while in the reflection (backward) mode the irradiation of the tissue of interest and detection of optoacoustic signals are performed from the same hemisphere. Recently, we developed new, transmission-mode optoacoustic probes for patients with traumatic brain injury (TBI) and for neonatal patients. The transmission mode probes have two major parts: a fiber-optic delivery system and an acoustic transducer (sensor). To obtain optoacoustic signals in the transmission mode, in this study we placed the sensor on the forehead, while light was delivered to the opposite side of the head. Using a medical grade, multi-wavelength, OPObased optoacoustic system tunable in the near infrared spectral range (680-950 nm) and a novel, compact, fiber-coupled, multi-wavelength, pulsed laser diode-based system, we recorded optoacoustic signals generated in the posterior part of the head of adults with TBI and neonates. The optoacoustic signals had two distinct peaks: the first peak from the intracranial space and the second peak from the scalp. The first peak generated by cerebral blood was used to measure cerebral blood oxygenation. Moreover, the transmission mode measurements provided detection of intracranial hematomas in the TBI patients. The obtained results suggest that the transmission mode can be used for optoacoustic brain imaging, tomography, and mapping in humans.
AB - We proposed to use transmission (forward) mode for cerebral, noninvasive, transcranial optoacoustic monitoring, imaging, and sensing in humans. In the transmission mode, the irradiation of the tissue of interest and detection of optoacoustic signals are performed from opposite hemispheres, while in the reflection (backward) mode the irradiation of the tissue of interest and detection of optoacoustic signals are performed from the same hemisphere. Recently, we developed new, transmission-mode optoacoustic probes for patients with traumatic brain injury (TBI) and for neonatal patients. The transmission mode probes have two major parts: a fiber-optic delivery system and an acoustic transducer (sensor). To obtain optoacoustic signals in the transmission mode, in this study we placed the sensor on the forehead, while light was delivered to the opposite side of the head. Using a medical grade, multi-wavelength, OPObased optoacoustic system tunable in the near infrared spectral range (680-950 nm) and a novel, compact, fiber-coupled, multi-wavelength, pulsed laser diode-based system, we recorded optoacoustic signals generated in the posterior part of the head of adults with TBI and neonates. The optoacoustic signals had two distinct peaks: the first peak from the intracranial space and the second peak from the scalp. The first peak generated by cerebral blood was used to measure cerebral blood oxygenation. Moreover, the transmission mode measurements provided detection of intracranial hematomas in the TBI patients. The obtained results suggest that the transmission mode can be used for optoacoustic brain imaging, tomography, and mapping in humans.
KW - cerebral ischemia
KW - cerebral oxygenation
KW - imaging
KW - noninvasive monitoring
KW - Optoacoustic
UR - http://www.scopus.com/inward/record.url?scp=84975041798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975041798&partnerID=8YFLogxK
U2 - 10.1117/12.2218919
DO - 10.1117/12.2218919
M3 - Conference contribution
VL - 9708
BT - Photons Plus Ultrasound: Imaging and Sensing 2016
PB - SPIE
ER -