Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory

N. Jaax, P. Jahrling, T. Geisbert, J. Geisbert, K. Steele, K. McKee, D. Nagley, E. Johnson, G. Jaax, C. Peters

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Abstract

Secondary transmission of Ebola virus infection in humans is known to be caused by direct contact with infected patients or body fluids. We report transmission of Ebola virus (Zaire strain) to two of three control rhesus monkeys (Macaca mulatta) that did not have direct contact with experimentally inoculated monkeys held in the same room. The two control monkeys died from Ebola virus infections at 10 and 11 days after the last experimentally inoculated monkey had died. The most likely route of infection of the control monkeys was aerosol, oral, or conjunctival exposure to virus-laden droplets secreted or excreted from the experimentally inoculated monkeys. These observations suggest approaches to the study of routes of transmission to and among humans.

Original languageEnglish (US)
Pages (from-to)1669-1671
Number of pages3
JournalThe Lancet
Volume346
Issue number8991-8892
DOIs
StatePublished - Dec 30 1995
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jaax, N., Jahrling, P., Geisbert, T., Geisbert, J., Steele, K., McKee, K., Nagley, D., Johnson, E., Jaax, G., & Peters, C. (1995). Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory. The Lancet, 346(8991-8892), 1669-1671. https://doi.org/10.1016/S0140-6736(95)92841-3