Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory

N. Jaax, P. Jahrling, Thomas Geisbert, J. Geisbert, K. Steele, K. McKee, D. Nagley, E. Johnson, G. Jaax, C. Peters

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Secondary transmission of Ebola virus infection in humans is known to be caused by direct contact with infected patients or body fluids. We report transmission of Ebola virus (Zaire strain) to two of three control rhesus monkeys (Macaca mulatta) that did not have direct contact with experimentally inoculated monkeys held in the same room. The two control monkeys died from Ebola virus infections at 10 and 11 days after the last experimentally inoculated monkey had died. The most likely route of infection of the control monkeys was aerosol, oral, or conjunctival exposure to virus-laden droplets secreted or excreted from the experimentally inoculated monkeys. These observations suggest approaches to the study of routes of transmission to and among humans.

Original languageEnglish (US)
Pages (from-to)1669-1671
Number of pages3
JournalThe Lancet
Volume346
Issue number8991-8892
DOIs
StatePublished - Dec 30 1995
Externally publishedYes

Fingerprint

Ebolavirus
Haplorhini
Ebola Hemorrhagic Fever
Macaca mulatta
Body Fluids
Infection Control
Aerosols
Viruses

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jaax, N., Jahrling, P., Geisbert, T., Geisbert, J., Steele, K., McKee, K., ... Peters, C. (1995). Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory. The Lancet, 346(8991-8892), 1669-1671. https://doi.org/10.1016/S0140-6736(95)92841-3

Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory. / Jaax, N.; Jahrling, P.; Geisbert, Thomas; Geisbert, J.; Steele, K.; McKee, K.; Nagley, D.; Johnson, E.; Jaax, G.; Peters, C.

In: The Lancet, Vol. 346, No. 8991-8892, 30.12.1995, p. 1669-1671.

Research output: Contribution to journalArticle

Jaax, N, Jahrling, P, Geisbert, T, Geisbert, J, Steele, K, McKee, K, Nagley, D, Johnson, E, Jaax, G & Peters, C 1995, 'Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory', The Lancet, vol. 346, no. 8991-8892, pp. 1669-1671. https://doi.org/10.1016/S0140-6736(95)92841-3
Jaax, N. ; Jahrling, P. ; Geisbert, Thomas ; Geisbert, J. ; Steele, K. ; McKee, K. ; Nagley, D. ; Johnson, E. ; Jaax, G. ; Peters, C. / Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory. In: The Lancet. 1995 ; Vol. 346, No. 8991-8892. pp. 1669-1671.
@article{bee4f708619e4e4c934a333efbd64abe,
title = "Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory",
abstract = "Secondary transmission of Ebola virus infection in humans is known to be caused by direct contact with infected patients or body fluids. We report transmission of Ebola virus (Zaire strain) to two of three control rhesus monkeys (Macaca mulatta) that did not have direct contact with experimentally inoculated monkeys held in the same room. The two control monkeys died from Ebola virus infections at 10 and 11 days after the last experimentally inoculated monkey had died. The most likely route of infection of the control monkeys was aerosol, oral, or conjunctival exposure to virus-laden droplets secreted or excreted from the experimentally inoculated monkeys. These observations suggest approaches to the study of routes of transmission to and among humans.",
author = "N. Jaax and P. Jahrling and Thomas Geisbert and J. Geisbert and K. Steele and K. McKee and D. Nagley and E. Johnson and G. Jaax and C. Peters",
year = "1995",
month = "12",
day = "30",
doi = "10.1016/S0140-6736(95)92841-3",
language = "English (US)",
volume = "346",
pages = "1669--1671",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8991-8892",

}

TY - JOUR

T1 - Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory

AU - Jaax, N.

AU - Jahrling, P.

AU - Geisbert, Thomas

AU - Geisbert, J.

AU - Steele, K.

AU - McKee, K.

AU - Nagley, D.

AU - Johnson, E.

AU - Jaax, G.

AU - Peters, C.

PY - 1995/12/30

Y1 - 1995/12/30

N2 - Secondary transmission of Ebola virus infection in humans is known to be caused by direct contact with infected patients or body fluids. We report transmission of Ebola virus (Zaire strain) to two of three control rhesus monkeys (Macaca mulatta) that did not have direct contact with experimentally inoculated monkeys held in the same room. The two control monkeys died from Ebola virus infections at 10 and 11 days after the last experimentally inoculated monkey had died. The most likely route of infection of the control monkeys was aerosol, oral, or conjunctival exposure to virus-laden droplets secreted or excreted from the experimentally inoculated monkeys. These observations suggest approaches to the study of routes of transmission to and among humans.

AB - Secondary transmission of Ebola virus infection in humans is known to be caused by direct contact with infected patients or body fluids. We report transmission of Ebola virus (Zaire strain) to two of three control rhesus monkeys (Macaca mulatta) that did not have direct contact with experimentally inoculated monkeys held in the same room. The two control monkeys died from Ebola virus infections at 10 and 11 days after the last experimentally inoculated monkey had died. The most likely route of infection of the control monkeys was aerosol, oral, or conjunctival exposure to virus-laden droplets secreted or excreted from the experimentally inoculated monkeys. These observations suggest approaches to the study of routes of transmission to and among humans.

UR - http://www.scopus.com/inward/record.url?scp=19144371555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19144371555&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(95)92841-3

DO - 10.1016/S0140-6736(95)92841-3

M3 - Article

VL - 346

SP - 1669

EP - 1671

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8991-8892

ER -