Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine: A randomized, double-blind study

Rhonda Robert, Win J. Tcheung, Laura Rosenberg, Marta Rosenberg, Charles Mitchell, Cynthia Villarreal, Christopher Thomas, Charles Holzer, Walter Meyer

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Introduction. For pediatric burn patients with the symptoms of acute stress disorder (ASD) a first line medication is not widely agreed upon. A prospective, randomized, placebo controlled, double-blind design was used to test the efficacy of imipramine and fluoxetine. Method. Patients 4-18 years of age with symptoms of ASD were randomized to 1 of 3 groups: imipramine, fluoxetine, or placebo for 1 week. Daily imipramine dose was 1 mg/kg, with the maximum dose being 100 mg. Daily fluoxetine dose was 5 mg for children weighing ≥40 kg; 10 mg for those weighing between 40 and 60 kg; 20 mg for those weighing >60 kg. Results. Sixty participants, 16 females and 44 males, had an average body surface area burn of 53% (S.D. = 18) and average age of 11 years (S.D. = 4). Imipramine subjects received an average daily dose of 1.00 ± 0.29 mg/kg. Fluoxetine subjects received an average daily dose of 0.29 ± 0.16 mg/kg. Between group differences were not detected. Fifty-five percent responded positively to placebo; 60% responded positively to imipramine; and 72% responded positively to fluoxetine. Conclusion. Within the parameters of this study design and sample, placebo was statistically as effective as either drug in treating symptoms of ASD.

Original languageEnglish (US)
Pages (from-to)919-928
Number of pages10
JournalBurns
Volume34
Issue number7
DOIs
StatePublished - Nov 2008

Fingerprint

Imipramine
Fluoxetine
Double-Blind Method
Stress Disorders, Traumatic, Acute
Placebos
Body Surface Area
Pediatrics
Pharmaceutical Preparations

Keywords

  • Acute stress disorder
  • Burn injury
  • Fluoxetine
  • Imipramine

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

Cite this

Robert, R., Tcheung, W. J., Rosenberg, L., Rosenberg, M., Mitchell, C., Villarreal, C., ... Meyer, W. (2008). Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine: A randomized, double-blind study. Burns, 34(7), 919-928. https://doi.org/10.1016/j.burns.2008.04.009

Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine : A randomized, double-blind study. / Robert, Rhonda; Tcheung, Win J.; Rosenberg, Laura; Rosenberg, Marta; Mitchell, Charles; Villarreal, Cynthia; Thomas, Christopher; Holzer, Charles; Meyer, Walter.

In: Burns, Vol. 34, No. 7, 11.2008, p. 919-928.

Research output: Contribution to journalArticle

Robert, R, Tcheung, WJ, Rosenberg, L, Rosenberg, M, Mitchell, C, Villarreal, C, Thomas, C, Holzer, C & Meyer, W 2008, 'Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine: A randomized, double-blind study', Burns, vol. 34, no. 7, pp. 919-928. https://doi.org/10.1016/j.burns.2008.04.009
Robert, Rhonda ; Tcheung, Win J. ; Rosenberg, Laura ; Rosenberg, Marta ; Mitchell, Charles ; Villarreal, Cynthia ; Thomas, Christopher ; Holzer, Charles ; Meyer, Walter. / Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine : A randomized, double-blind study. In: Burns. 2008 ; Vol. 34, No. 7. pp. 919-928.
@article{c61c5cfe9e8d47d49791db61cba6fc82,
title = "Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine: A randomized, double-blind study",
abstract = "Introduction. For pediatric burn patients with the symptoms of acute stress disorder (ASD) a first line medication is not widely agreed upon. A prospective, randomized, placebo controlled, double-blind design was used to test the efficacy of imipramine and fluoxetine. Method. Patients 4-18 years of age with symptoms of ASD were randomized to 1 of 3 groups: imipramine, fluoxetine, or placebo for 1 week. Daily imipramine dose was 1 mg/kg, with the maximum dose being 100 mg. Daily fluoxetine dose was 5 mg for children weighing ≥40 kg; 10 mg for those weighing between 40 and 60 kg; 20 mg for those weighing >60 kg. Results. Sixty participants, 16 females and 44 males, had an average body surface area burn of 53{\%} (S.D. = 18) and average age of 11 years (S.D. = 4). Imipramine subjects received an average daily dose of 1.00 ± 0.29 mg/kg. Fluoxetine subjects received an average daily dose of 0.29 ± 0.16 mg/kg. Between group differences were not detected. Fifty-five percent responded positively to placebo; 60{\%} responded positively to imipramine; and 72{\%} responded positively to fluoxetine. Conclusion. Within the parameters of this study design and sample, placebo was statistically as effective as either drug in treating symptoms of ASD.",
keywords = "Acute stress disorder, Burn injury, Fluoxetine, Imipramine",
author = "Rhonda Robert and Tcheung, {Win J.} and Laura Rosenberg and Marta Rosenberg and Charles Mitchell and Cynthia Villarreal and Christopher Thomas and Charles Holzer and Walter Meyer",
year = "2008",
month = "11",
doi = "10.1016/j.burns.2008.04.009",
language = "English (US)",
volume = "34",
pages = "919--928",
journal = "Burns",
issn = "0305-4179",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine

T2 - A randomized, double-blind study

AU - Robert, Rhonda

AU - Tcheung, Win J.

AU - Rosenberg, Laura

AU - Rosenberg, Marta

AU - Mitchell, Charles

AU - Villarreal, Cynthia

AU - Thomas, Christopher

AU - Holzer, Charles

AU - Meyer, Walter

PY - 2008/11

Y1 - 2008/11

N2 - Introduction. For pediatric burn patients with the symptoms of acute stress disorder (ASD) a first line medication is not widely agreed upon. A prospective, randomized, placebo controlled, double-blind design was used to test the efficacy of imipramine and fluoxetine. Method. Patients 4-18 years of age with symptoms of ASD were randomized to 1 of 3 groups: imipramine, fluoxetine, or placebo for 1 week. Daily imipramine dose was 1 mg/kg, with the maximum dose being 100 mg. Daily fluoxetine dose was 5 mg for children weighing ≥40 kg; 10 mg for those weighing between 40 and 60 kg; 20 mg for those weighing >60 kg. Results. Sixty participants, 16 females and 44 males, had an average body surface area burn of 53% (S.D. = 18) and average age of 11 years (S.D. = 4). Imipramine subjects received an average daily dose of 1.00 ± 0.29 mg/kg. Fluoxetine subjects received an average daily dose of 0.29 ± 0.16 mg/kg. Between group differences were not detected. Fifty-five percent responded positively to placebo; 60% responded positively to imipramine; and 72% responded positively to fluoxetine. Conclusion. Within the parameters of this study design and sample, placebo was statistically as effective as either drug in treating symptoms of ASD.

AB - Introduction. For pediatric burn patients with the symptoms of acute stress disorder (ASD) a first line medication is not widely agreed upon. A prospective, randomized, placebo controlled, double-blind design was used to test the efficacy of imipramine and fluoxetine. Method. Patients 4-18 years of age with symptoms of ASD were randomized to 1 of 3 groups: imipramine, fluoxetine, or placebo for 1 week. Daily imipramine dose was 1 mg/kg, with the maximum dose being 100 mg. Daily fluoxetine dose was 5 mg for children weighing ≥40 kg; 10 mg for those weighing between 40 and 60 kg; 20 mg for those weighing >60 kg. Results. Sixty participants, 16 females and 44 males, had an average body surface area burn of 53% (S.D. = 18) and average age of 11 years (S.D. = 4). Imipramine subjects received an average daily dose of 1.00 ± 0.29 mg/kg. Fluoxetine subjects received an average daily dose of 0.29 ± 0.16 mg/kg. Between group differences were not detected. Fifty-five percent responded positively to placebo; 60% responded positively to imipramine; and 72% responded positively to fluoxetine. Conclusion. Within the parameters of this study design and sample, placebo was statistically as effective as either drug in treating symptoms of ASD.

KW - Acute stress disorder

KW - Burn injury

KW - Fluoxetine

KW - Imipramine

UR - http://www.scopus.com/inward/record.url?scp=50949097934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50949097934&partnerID=8YFLogxK

U2 - 10.1016/j.burns.2008.04.009

DO - 10.1016/j.burns.2008.04.009

M3 - Article

C2 - 18675519

AN - SCOPUS:50949097934

VL - 34

SP - 919

EP - 928

JO - Burns

JF - Burns

SN - 0305-4179

IS - 7

ER -