Treatment of Burned Mice With Hyperbaric Oxygen Reduces Mesenteric Bacteria but Not Pulmonary Neutrophil Deposition

Mayer Tenenhaus; John F. Hansbrough; Ramon Zapata Sirvent; Tom Neumann

doi:10.1001/archsurg.1994.01420360128018

Treatment of Burned Mice With Hyperbaric Oxygen Reduces Mesenteric Bacteria but Not Pulmonary Neutrophil Deposition

Mayer Tenenhaus, John F. Hansbrough, Ramon Zapata Sirvent, Tom Neumann

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

HBO therapy was associated with reduced numbers of mice with MBCs after burn injury and reduced histologic evidence of mucosal damage, but lung myeloperoxidase levels and metabolic acidosis were not affected. HBO therapy may increase oxygen delivery to ischemic intestine and improve cellular metabolism; alternatively, increased tissue oxygen may augment killing of translocated bacteria by phagocytic cells. HBO deserves further investigation for burn treatment, but because of the narrow therapeutic window and continued neutrophil sequestration in the lungs, we should proceed cautiously. (Arch Surg. 1994;129:1338-1342).

Original language	English (US)
Pages (from-to)	1338-1342
Number of pages	5
Journal	Archives of Surgery
Volume	129
Issue number	12
DOIs	https://doi.org/10.1001/archsurg.1994.01420360128018
State	Published - Dec 1994
Externally published	Yes

ASJC Scopus subject areas

Surgery

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title = "Treatment of Burned Mice With Hyperbaric Oxygen Reduces Mesenteric Bacteria but Not Pulmonary Neutrophil Deposition",

abstract = "HBO therapy was associated with reduced numbers of mice with MBCs after burn injury and reduced histologic evidence of mucosal damage, but lung myeloperoxidase levels and metabolic acidosis were not affected. HBO therapy may increase oxygen delivery to ischemic intestine and improve cellular metabolism; alternatively, increased tissue oxygen may augment killing of translocated bacteria by phagocytic cells. HBO deserves further investigation for burn treatment, but because of the narrow therapeutic window and continued neutrophil sequestration in the lungs, we should proceed cautiously. (Arch Surg. 1994;129:1338-1342).",

author = "Mayer Tenenhaus and Hansbrough, {John F.} and {Zapata Sirvent}, Ramon and Tom Neumann",

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AU - Neumann, Tom

PY - 1994/12

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AB - HBO therapy was associated with reduced numbers of mice with MBCs after burn injury and reduced histologic evidence of mucosal damage, but lung myeloperoxidase levels and metabolic acidosis were not affected. HBO therapy may increase oxygen delivery to ischemic intestine and improve cellular metabolism; alternatively, increased tissue oxygen may augment killing of translocated bacteria by phagocytic cells. HBO deserves further investigation for burn treatment, but because of the narrow therapeutic window and continued neutrophil sequestration in the lungs, we should proceed cautiously. (Arch Surg. 1994;129:1338-1342).

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Treatment of Burned Mice With Hyperbaric Oxygen Reduces Mesenteric Bacteria but Not Pulmonary Neutrophil Deposition

Abstract

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