Treatment of Burned Mice With Hyperbaric Oxygen Reduces Mesenteric Bacteria but Not Pulmonary Neutrophil Deposition

Mayer Tenenhaus, John F. Hansbrough, Ramon Zapata Sirvent, Tom Neumann

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

HBO therapy was associated with reduced numbers of mice with MBCs after burn injury and reduced histologic evidence of mucosal damage, but lung myeloperoxidase levels and metabolic acidosis were not affected. HBO therapy may increase oxygen delivery to ischemic intestine and improve cellular metabolism; alternatively, increased tissue oxygen may augment killing of translocated bacteria by phagocytic cells. HBO deserves further investigation for burn treatment, but because of the narrow therapeutic window and continued neutrophil sequestration in the lungs, we should proceed cautiously. (Arch Surg. 1994;129:1338-1342).

Original languageEnglish (US)
Pages (from-to)1338-1342
Number of pages5
JournalArchives of Surgery
Volume129
Issue number12
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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