Treatment of Cryptosporidiosis With Paromomycin: A Report of Five Cases

Keith Armitage, Timothy Flanigan, John Carey, Ian Frank, Rob Roy Macgregor, Paul Ross, Richard Goodgame, John Turner

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Cryptosporidiosis continues to be one of the most devastating complications of the acquired immunodeficiency syndrome, causing severe, chronic diarrhea that is largely refractory to treatment. More than 60 drugs have been tried in the treatment of cryptosporidiosis, none of which have been consistently successful. We describe the successful treatment of cryptosporidiosis in five patients with acquired immunodeficiency syndrome with oral paromomycin at a dose of 1500 to 2000 mg/d. All five patients had resolution of symptoms and normalization of bowel movements, although one patient later relapsed while receiving paromomycin. Three of five patients cleared Cryptosporidium from the stool. Paromomycin is a promising therapy for cryptosporidiosis in acquired immunodeficiency syndrome and further prospective clinical trials are warranted.

Original languageEnglish (US)
Pages (from-to)2497-2499
Number of pages3
JournalArchives of Internal Medicine
Volume152
Issue number12
DOIs
StatePublished - Dec 1992

ASJC Scopus subject areas

  • Internal Medicine

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    Armitage, K., Flanigan, T., Carey, J., Frank, I., Macgregor, R. R., Ross, P., Goodgame, R., & Turner, J. (1992). Treatment of Cryptosporidiosis With Paromomycin: A Report of Five Cases. Archives of Internal Medicine, 152(12), 2497-2499. https://doi.org/10.1001/archinte.1992.00400240111018